ד"ר מורן דבלה לויט

1.      Wieder N, Fried JC, Kim C, Sidhom EH, Brown MR, Marshall JL, Arevalo C, Dvela-Levitt M, Kost-Alimova M, Sieber J, Gabriel KR, Pacheco J, Clish C, Abbasi HS, Singh S, Rutter JC, Therrien M, Yoon H, Lai ZW, Baublis A, Subramanian R, Devkota R, Small J, Sreekanth V, Han M, Lim D, Carpenter AE, Flannick J, Finucane H, Haigis MC, Claussnitzer M, Sheu E, Stevens B, Wagner BK, Choudhary A, Shaw JL, Pablo JL, Greka A. (2023)
FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.

Cell Metab.35(5):887-905

https://pubmed.ncbi.nlm.nih.gov/37075753/

2.      Dvela-Levitt M. (2021)

Feed the Flames. Stories in Molecular Medicine.

Trends in Molecular Medicine. 27(4):293-296

https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(21)00043-5#.YEfspfBBv28.twitter

3.      Dvela-Levitt M, Shaw LJ, and Greka A. (2021)

A rare kidney disease to cure them all? Towards mechanism-based therapies for proteinopathies.

Trends in Molecular Medicine. 16;S1471-4914(20)30312-9

https://pubmed.ncbi.nlm.nih.gov/33341352/

4.      Alimova M, Sidhom E, Satyam A, Dvela-Levitt M, Melanson M, Chamberlain1 BT, Alper SL, Santos J, Gutierrez J, Subramanian A, Grinkevich E, Bricio ER, KimC, Clark A, Watts A, Thompson R, Marshall J, Pablo JL, Coraor J, Roignot J, Vernon KA, Keller K, Campbell A, Emani M, Racette M, Bazua-Valenti S, Padovano V, Weins A, McAdoo SP, Tam F, Ronco L, Wagner F, Tsokos GC, Shaw JL, Greka. (2020)

A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic

Cell Reports Medicine 1 (8)

https://www.sciencedirect.com/science/article/pii/S2666379120301816

5.       Dvela-Levitt M, Kost-Alimova M, Emani M, Kohnert E, Thompson R, Sidhom EH, Rivadeneira A, Sahakian N, Roignot J, Papagregoriou G, Montesinos MS, Clark AR, McKinney D, Gutierrez J, Roth M, Ronco L, Elonga E, Carter T, Gnirke A, Melanson M, Hartland K, Wieder N, Hsu JCH, Deltas C, Hughey R, Bleyer AJ, Kmoch S, Živná M, Barešova V, Kota S, Schlondorff J, Heiman M, Alper SL, Wagner F, Weins A, Golub TR, Lander ES, Greka A. (2019)

Small molecule targets TMED9 and promotes lysosomal degradation to reverse proteinopathy.

Cell. 178(3):521-535.

https://www.sciencedirect.com/science/article/pii/S009286741930741X?dgcid=coauthor

6.       Zhou Y, Castonguay P, Sidhom EH, Clark AR, Dvela-Levitt M, Kim S, Sieber J, Wieder N, Jung JY, Andreeva S, Reichardt J, Dubois F, Hoffmann SC, Basgen JM, Montesinos MS, Weins A, Johnson AC, Lander ES, Garrett MR, Hopkins CR, Greka A. (2017)

A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models.

Science. 8;358(6368):1332-1336.

https://www.ncbi.nlm.nih.gov/pubmed/29217578

7.       Sieber J, Wieder N, Ostrosky-Frid M, Dvela-Levitt M, Aygün O, Udeshi ND, Carr SA, Greka A. (2017)

Lysine trimethylation regulates 78-kDa glucose-regulated protein proteostasis during endoplasmic reticulum stress. 

J Biol Chem. 17;292(46):18878-18885.

https://www.ncbi.nlm.nih.gov/pubmed/28912266

8.       Dvela-Levitt M, Cohen-Ben Ami H, Rosen H, Ornoy A, Hochner-Celnikier D, Granat M and Lichtstein D. (2015)

Reduction in maternal circulating ouabain impairs offspring growth and kidney development.

J. Am. Soc. Nephrol. 26(5):1103-1.

http://www.ncbi.nlm.nih.gov/pubmed/25294233

9.       Dvela-Levitt M, Cohen-Ben Ami H, Rosen H, Shohami E and Lichtstein D. (2014)

Ouabain improves functional recovery following traumatic brain injury.

J Neurotrauma. 1;31(23):1942-7.

http://www.ncbi.nlm.nih.gov/pubmed/25007121

10.    Lichtstein D, Rosen H and Dvela M. (2012)

Cardenolides and bufadienolides as hormones: What is missing?

Am. J. Physiol. Renal Physiol. 302(8):F957-8. *Commentary

       http://www.ncbi.nlm.nih.gov/pubmed/22301627

11.    Dvela M, Rosen H, Cohen-Ben Ami H and Lichtstein D. (2012)

Endogenous ouabain regulates cell viability.

Am J Physiol Cell Physiol. 302(2):C442-52.

http://www.ncbi.nlm.nih.gov/pubmed/22031604

12.    Jaiswal M, Dvela M, Lichtstein D and Mallick B. (2010)

Endogenous Ouabain-Like Compounds in Locus Coeruleus Modulate Rapid Eye Movement Sleep in Rats.

J. Sleep Res. 19(1 Pt 2):183-91.

       http://www.ncbi.nlm.nih.gov/pubmed/19878449

13.    Nesher M, Shpolansky U, Viola N, Dvela M, Buzaglo N, Cohen Ben-Ami H, Rosen H and Lichtstein D. (2010)

Ouabain attenuates cardiotoxicity induced by other cardiac steroids.

Br. J. Pharmacol. 160(2):346-54.

       http://www.ncbi.nlm.nih.gov/pubmed/20423344

14.    Nesher M, Dvela M, Igbokwe VU, Rosen H, and Lichtstein D. (2009)

Physiological roles of endogenous ouabain in normal rat. 

Am. J. Physiol. Heart Circ Physiol. 297(6):H2026-34.

       http://www.ncbi.nlm.nih.gov/pubmed/19837951

15.    Dvela M, Rosen H, Feldmann T, Nesher M and Lichtstein D. (2007)

Diverse biological responses to different cardiotonic steroids.

Pathophysiology. 14: 159-66. *Review article

       http://www.ncbi.nlm.nih.gov/pubmed/17964766