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פרופ' מירה ברדה-סעד

פרופסור מן המניין
בנין מחקר רפואי אבחוני ע"ש גונדה 204, קומה ב', חדר 203
  1. Barda-Saad, M. Sredni, D., Zemer, R., Lenz, R. and Rozensajn L.A. (1990). T-lymphocyte colony enhancing factor. Harefuah 118: 92-5.
  2. Barda-Saad, M., Zipori, D., Globerson, A., Zhang, A.S. and Rozenszajn, L.A. (1996). Selective adhesion of immature thymocytes to bone marrow stromal cells: relevance to T cell lymphopoiesis.Exp Hematol. 24: 386-91.
  3. Barda-Saad, M., Zhang, A.S., Zipori, D. and Rozenszajn, L.A. (1997). Adhesion of thymocytes to bone marrow stroma cells: regulation by bFGF and IFN-gamma. Stem Cells 15: 229-36.
  4. Yu, S., Wang, S.L., Zhang, H.W., Huang, Z., Abel, L., Barda-Saad, M., Zipori, D. and Globerson, A. (1998). Effect of aging on the expression of surface antigen in mouse thymocytes. Acta Zoologica Sinica, 44:466-474.
  5. Barda-Saad, M., Rozenszajn, LA, Ashush, H., Shav-Tal, Y., Ben-Nun, A. and Zipori, D. (1999). Adhesion molecules involved in the interactions between early T-cells and mesenchymal bone marrow stromal cells. Exp Hematol. 27: 834-44.
  6. Ashush, H., Rozenszajn, LA, Blass, M., Barda-Saad, M., Azimov, D., Radnay, J., Zipori, D. and Rosenschein U. (2000). Apoptosis induction of human myeloid leukemic cells by ultrasound exposure. Cancer Res. 60:1014-20.
  7. Zipori, D., Barda-Saad, M. (2001). Role of activin A in negative regulation of normal and tumor B lymphocytes. J. Leukoc. Biol. 69:867-73.
  8. Shoham, T., Sternberg, D., Brosh, N., Barda-Saad, M. and Zipori D. (2001). The promotion of plasmacytoma growth by mesenchymal stroma is antagonized by basic fibroblast growth factor induced activin A. Leukemia 15:1102-10.
  9. Barda-Saad, M., Shav-Tal, Y., Rozenszajn, L.A., Cohen, M., Zauberman, A., Karmazyn, A., Parameswaran, R, Schori, H, Ashush, H., Ben-Nun, A. and Zipori D. (2002). The mesenchyme expresses T cell receptor mRNAs: relevance to cell growth control. Oncogene 21:2029-36.
  10. Shoham, T., Parameswaran, R., Shav-Tal, Y., Barda-Saad, M., and Zipori D. (2003). The Mesenchymal stroma negatively regulates B cell lymphopoiesis through the expression of activin A.Ann. N Y Acad. Sci. 996:245-260.
  11. Barda-Saad, M.,  Braiman, A.,  Titerence, R.,   Bunnell, S.C.,   Barr, V.A.,  and Samelson,  L.E. (2005) Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton.Nature Immunology 6:80-89.
  12. Houtman, J.C., Houghtling, R., Barda-Saad, M., Toda, Y., Schwartzberg, PL., and Samelson, LE. (2005). Early phosphorylation kinetics of proteins involved in proximal T-cell receptor-mediated signaling pathways. J. Immunol. 15:2449-2458.
  13. Houtman, J.C., Barda-Saad, M. and Samelson, L.E. (2005). Examining multiprotein signaling complexes from all angles. The use of complementary techniques to characterize complex formation at the adapter protein LAT. FEBS J. 272:5426-35.
  14. Barda-Saad, M., Braiman, A., Titerence, R., Barr, V. and Samelson, L.E. (2006). T cell antigen receptor engagement induced cytoskeleton re-organization. CCR Frontiers in Science (Published by the National Cancer Institute’s Center for Cancer Research, NIH).
  15. Braiman, A., Barda-Saad, M. and Samelson, L.E. (2006). Recruitment and activation of PLCg1in T-cells: a new insight into old domains. EMBO J. 25:774-84.
  16. Barr, V.A., Balagopalan-Bhise, L., Barda-Saad, M., Polishchuk, R., Boukari, H.,
    Bunnell, S.C., Bernot, K.M., Toda, Y., Nossal, R., and Samelson,  L.E. (2006). T-cell antigen receptor-induced signaling complexes: Internalization via a cholesterol-dependent endocytic pathway. Traffic 7:1143-1163.
  17. Houtman, J.C., Yamaguchi, H., Barda-Saad, M., Bowden, B., Schuck, P., Appella, E., and Samelson, LE. (2006). Oligomerization of signaling complexes by the multipoint binding of Grb-2 to both LAT and Sos1. Nature Struct. Mol. Biol. 13:798-805.
  18. Balagopalan, L., Barr, V.A., Sommers, C.L., Barda-Saad, M., Goyal, A., Isakowitz, M.S. and Samelson, L.E. (2007). c-Cbl mediated regulation of LAT-nucleated signaling complexes. Mol. Cell. Biol. 27:8622-8636.
  19. Sommers, C., Gurson, J.M., Surana, R., Barda-Saad, M., Lee, J., Kishor, A., Li, W.,
    Gasser, A.J., Barr, V., Miyaji, M., Love, P. and Samelson, L.E. (2008) Bam-32: a novel mediator of Erk activation in T cells. Int. Immunol. 20:811-818.
  20. Shani N, Rubin-Lifshitz, H., Sccolnick, K., Peretz-Chohen Y. Shkolnik, K., Shnider, V., Cohen, M., Shav-Tal, Y., Barda-Saad, M. and Zipori D. (2009) Incomplete T-cell receptor-beta peptides target the mitochondrion and induce apoptosis. Blood. 9:3530-3541.
  21. Barda-Saad, M, Shirasu, N., Pauker M.H, Hasan, N., Perl, O., Balbo, A., Yamaguchi, H., Houtman, J., Appella, E., Schuck, P. and Samelson, LE. (2010) Cooperative interactions at the SLP-76 complex are critical for actin polymerization. EMBO J. 29:2315-2328Single Corresponding author
  22. Reicher, B. and Barda-Saad, M. (2010). Multiple Pathways leading from the T-cell antigen receptor to the actin cytoskeleton network. FEBS Lett. 584:4858-4864.  Single Corresponding author
  23. Hazani, M. and Barda-Saad, M. (2010). Studies of novel interactions between Nck and VAV SH3 domains. Comm. Integ. Biol. 4:175-177Invited, Single Corresponding author
  24. Pauker, H.M., Reicher, B., Fried, S., Perl, O., and Barda-Saad, M. (2011) Functional cooperation between the proteins Nck and ADAP is fundamental for actin reorganization. Mol Cell Biol. 31;2653-2666.  Single Corresponding author
  25. Pauker, H.M., Hassan, N. Noy, E. Reicher, B. and Barda-Saad, M. (2012) Studying the dynamics of SLP-76, Nck, and Vav1 multimolecular complex formation in live human cells with triple-color FRET.Science Signaling 5(221):rs3 (cover). Single Corresponding author
  26. Reicher, B., Joseph, N., David, A., Perl, O. and Barda-Saad, M. (2012) Ubiquitylation-dependent negative regulation of WASp is essential for actin cytoskeleton dynamics. Mol. Cell. Biol. 32:3153.Single Corresponding author
  27. Noy, E., Fried, S. Matalon, O. and Barda-Saad M. (2012) WIP remodeling actin behind the scenes: How WIP reshapes immune and other functions. Int. J. Mol. Sci. 13:7629. Single Corresponding author
  28. Reicher, B., Perl, O., Matalon, O. and Barda-Saad, M. (2012) WASp and WAVE proteins: from structure, through function, to clinical aspects. Review, J. Clin. Cell. Immunol.,http://dx.doi.org/10.4172/2155-9899.S12-001Single Corresponding author
  29. Pauker, H.M., Noy, E. and Barda-Saad, M. (2013) Following the dynamics of signaling protein interactions in live activated T cells. JoVEhttp://www.jove.com/video/50076Single Corresponding author
  30. Ovadia, A., Livneh, A., Feld, O., Ben-Zvi, I., Kukuy, E., Kivity, S., Lidar, M., Barda-Saad, M. and Shinar, Y. (2013) T helper 17 polarization in familial Mediterranean fever. Genes & Immun. 1-5. doi: 10.1038/gene.2013.6.
  31. Joseph, N., Reicher, B. and Barda-Saad, M. (2013) The calcium feedback loop and T-cell activation: how the cytoskeleton networks control intracellular calcium levels. Biochimica et Biophysica Acta (BBA) – BiomembranesInvited, 105:481-93. Single Corresponding author
  32. Reicher, B., Matalon, O. and Barda-Saad, M. (2013) WASp function in T cell signaling microclusters. Immunol. RevInvited, 256:10-29. Single Corresponding author
  33. Haba, N.Y., Gross, R., Novacek, J., Shaked, H., Zidek, L., Barda-Saad, M. and Chill, J.H. (2013) NMR determines transient structure and dynamics in the disordered C-terminal domain of WASp interacting protein. Biophys. J. 105:481.
  34. Klieger, Y., Almogi-Hazan, O., Ish-Shalom, E., Pato, A., Pauker, H.M., Barda-Saad, M., Wang, L.  and Baniyash, M. (2013) Unique ζ-chain motifs mediate a direct TCR-actin linkage critical for immunological synapse formation and T-cell activation. Eur. J. Immunol. 44:58.
  35. Fried, S., Pauker, M. H., Reicher, B., Eliyahu, S., Matalon, O., Noy, E., Chill, J., and Barda-Saad, M. Conformational changes within the WIP:WASp actin-regulating complex: a triple-color FRET study.Science Signaling. Under Revision.  Single Corresponding author
  36. Elazari-Shalom, H., Shaked, H., Esteban-Martin, S., Salvatella, X., Barda-Saad, M. and Chill, J. (2014) NMR investigation of transient structure in the disordered N-terminal domain of WASp interacting protein. The FEBS JournalUnder revision.
  37. Borodianskiy-Shteinberg, T., Kalt, I., Kipper, S., Katz, S., Pauker, H. M., Barda-Saad, M., Gerber, D., and Sarid, R. (2014) The Nucleolar PICT-1/GLTSCR2 Protein Forms Homo-Oligomers. Journal of Molecular BiologyIn Press.
  38. Fried, S., Matalon, O., Noy, E., and Barda-Saad, M. (2014) WIP: More than a WASp interacting protein. Journal of leukocyte biologyUnder Revision.  Single Corresponding author
  39. Joseph, N., Reicher, B., Ahuvit D., Matalon, O., and Barda-Saad, M. (2014) Ubiquitylation-dependent downregulation of Nck  regulates its functional activity. FEBS Lett. 588:3808.
  40. Pauker, MH., Reicher, B., Wortzel1, I., Joseph, N., Jakubowicz, S., Perl, O., and Barda-Saad, M. (2014) WASp Family Verprolin-Homologous Protein-2 (WAVE2) and Wiskott-Aldrich Syndrome Protein (WASp) Engage in Distinct Downstream Signaling Interactions at the T Cell Antigen Receptor Site. JBC, 289:34503.
  41. Elazari-Shalom, H., Shaked, H., Esteban-Martin, S., Salvatella, X., Barda-Saad, M. and Chill, J. (2015) New insights into the role of the disordered WIP N-terminal domain revealed by NMR structural characterization. The FEBS Journal, 282:700.
  42. Ziv-Av, A., Giladi, ND., Lee, HK., Cazacu, S., Finniss, S., Xiang, C., Pauker, H.M., Barda-Saad, M., Poisson, L. and Brodie, C. (2015) RTVP-1 regulates glioma cell migration and invasion via interaction with N-WASP and hnRNPK. Oncotarget,  6:19826.
  43. Matalon, O., Fried, S., Ben-Shmuel, A., Pauker, H.M., Joseph, N., Keizer, D., Piterburg, M. and Barda-Saad, M. (2016) NK cell cytotoxicity is regulated by LAT and PLCgamma which serve as novel substrates of SHP-1. Science Signaling, 9 (429): ra54.

Chapters in Books

  1. Reicher, B., and Barda-Saad, M. (2011) Invited Book’s Chapter: The molecular mechanisms of actin regulatory proteins. Chapter 6 in: Actin: Structure, Functions and Disease (Online book edition). Eds: Victoria A. Consuelas and Daniel J. Minas. Nova Science Publishers, Inc.
  2. Elad, N., Reicher, B. and Barda-Saad, M. (2011) Invited Book’s Chapter: Stoichiometry of Signaling Complexes in Immune Cells: Regulation by the Numbers. Chapter 9 in: Stoichiometry and Research- The importance of quantity in biomedicine (Online book edition). Ed: Alessio Innocenti,InTech publications, Inc. 


  1. PCT/IL02/00130- #20040259196, T Cell Receptor variants expressed in Mesenchymal cells and uses thereof. Pending.
  2. PCT/IL02/00129 - #20040101931, Immunoglobulin Superfamily variants expressed in Mesenchymal cells and therapeutic uses thereof. US Pending. EP 1389236.
  3. #20070196365 – Immunoglobulin heavy chain variants expressed in mesenchymal cells and therapeutic uses thereof. Pending.

תאריך עדכון אחרון : 20/08/2020