Our laboratory studies the signal transduction mechanisms of immune cells and follows leukocyte behavior in health and disease. Specifically, we study the molecular mechanisms regulating T and Natural Killer (NK) cell immune response, to modulate their activation state and response under pathophysiological conditions, including cancer, primary immunodeficiencies, and chronic inflammation.
Our specific aims are:
- To determine the molecular mechanisms of NK cell immunity, we focus mainly on the negative signaling cascades which inhibit NK cell immune function.
- To determine the role of the cytoskeleton in immune cell behavior and malignant cell fate.
- To utilize artificial intelligence tools and machine learning platforms to identify small molecule compounds that target signaling cascade/s or protein/s crucial for modulating lymphocyte activity and behavior in pathophysiological conditions.
To perform our research, we apply multidisciplinary techniques, including molecular engineering, nanobiology, biochemical, and biophysical approaches, gene silencing using CRISPR technology, the use of organoids, and in vivo murine model systems. In addition, our studies utilize advanced microscopy techniques (live cell imaging, FRET), and spectral flow cytometry.