English

ד"ר עשהאל רויכמן

טלפון
972-3-7384295
דוא"ל
asael.roichman@biu.ac.il
משרד
בניין ננו 206, קומה 6, חדר C-662
תחומי מחקר
פרסומים

Peer-reviewed publications:

  1. Qiang H., Wang F., Lu W., Xing X., …, Roichman A., …, Shapiro A.M., Wishart D.S., Rabinowitz J.D. and Skinnider M.A. (2025) Language model-guided anticipation and discovery of unknown metabolites. Nature (In press).

  2. Fang C., Esposito M., Hars U., Byrne R.T., …, Roichman A., …, Wei Y., Cristea I.M., Rabinowitz J.D., and Kang Y. (2025). Targeting autocrine retinoic acid signaling by ALDH1A2 inhibition enhances anti-tumor dendritic cell vaccine efficacy. Nature Immunology (In press).

  3. Touitou N., Nahum L., Feldman S., Avivi M., …, Roichman A., …, Moaddel R., Geiger T., de Cabo R., and Cohen, H.Y. (2025). Sirt6 prevents the age-related decline of H2S through the control of one-carbon metabolism. Proc Natl Acad Sci USA, 122(46).

  4. Lea A.J., Caldas I.V., Garske K.M., Gerlinger E.R., …, Roichman A., …, Taravella Oill A.M., Mathew S., Wilson M.A., and Ayroles J.F. (2025). Adaptations to water stress and pastoralism in the Turkana of northwest Kenya. Science, 389(6766):1246-1251.

  5. Roichman A., Zuo Q., Hwang S., Lu W., …, Guo J.Y., Kang Y., Donia M.S., and Rabinowitz J.D. (2025) Microbiome Metabolism of Dietary Phytochemicals Controls the Anticancer Activity of PI3K Inhibitors. Cell, 188(11):3065-3080.

  6. Roichman A.*, Reyes-Castellanos G.*, Chen Ziq.*, Chen Zih.*, …, Wei Y., Kang Y., White E., and Rabinowitz J.D. (2025) Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models. Cancer Research, 85(17):3335-3347.

  7. Bartman CR., Weilandt, D.R., Shen Y., Lee W.D., …, Roichman A., …, Herranz D., Guo J.Y., Kang Y., and Rabinowitz J.D. (2023). Slow TCA flux and ATP production in primary solid tumours but not metastases. Nature, 614(7947):349-357.

  8. Kafri M., Patena W., Martin L., Wang L., …, Roichman A., …, Rabinowitz J.D., Cross F.R., Wühr M., Jonikas M.C. (2023). Systematic identification and characterization of genes in the regulation and biogenesis of photosynthetic machinery. Cell, 186(25):5638-5655.

  9. Zeng X., Xing X., Gupta M., Keber F.C., …, Roichman A., …., Donia M.S., Wühr M., Jang C., Rabinowitz J.D. (2022). Gut bacterial nutrient preferences quantified in vivo. Cell, 185(18):3441-3456.

  10. Katz A., Gonen M., Shahar Y., Roichman A., Lerrer B., and Cohen H.Y. (2022). Hypothalamus–Muscle Parallel Induction of Metabolic Pathways Following Physical Exercise. Front. Neurosci, 16:897005.

  11. Roichman A.*, Elhanati S.*, Aon M.A., Abramovich I., Di Francesco A., …, Fernández-Marcos P.J., Serrano M., Gottlieb E., de Cabo R., and Cohen H.Y. (2021). Restoration of Energy Homeostasis by SIRT6 Extends Healthy Lifespan. Nature communications. 12(1):3208.

#3 most downloaded Nature Communications article in health sciences published in 2021

  1. Andrawus, M., Sharvit, L., Shekhidem, H.A., Roichman, A., Cohen, H.Y., and Atzmon, G. (2020). The Effects of Environmental Stressors on Candidate Aging Associated Genes. Experimental Gerontology, 137:110952.

  2. Naiman S., Huynh F.K., Gil R., Glick Y., …, Roichman A., …, Gottlieb E., Harris R.A., Gerber D., Hirschey M.D., and Cohen H.Y. (2019). SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα. Cell reports. 29 (12), 4127-4143.

  1. Adwan Shekhidem H., Sharvit L., Leman E., Manov I., Roichman A., Holtze S., Huffman D.M., Cohen H.Y., Hildebrandt T.B., Shams I., and Atzmon G. (2019). Telomeres and Longevity; a Cause or an Effect. International Journal of Molecular Sciences. 20(13), 3233.

  2. Lev-Vachnish, Y., Cadury, S., Rotter-Maskowitz, A., Feldman, N., Roichman, A., Illouz, T., Varvak, A., Nicola, R., Madar, R., and Okun, E. (2019). L-Lactate Promotes Adult Hippocampal Neurogenesis. Frontiers in Neuroscience. 13, 403.

  3. Simon M., Van Meter M., Ablaeva J., Ke Z., Gonzalez R.S., …, Roichman A., Cohen H.Y., …, Gudkov A.V., Sedivy J.M., Seluanov A., and Gorbunova V. (2019). LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation. Cell Metabolism. 30, 1–15.

  4. Roichman, A., Kanfi, Y., Glazz, R., Naiman, S., …, Pikarsky E., Leor J., and Cohen, H.Y. (2017). SIRT6 Overexpression Improves Various Aspects of Mouse Healthspan. J Gerontol A Biol Sci Med Sci. 72(5), 603-615.

  5. Shalev A., Benarroch F., Goltser-Dubner T., Canetti L., Saloner C., Roichman A., Cohen H., Galili-Weisstub E., and Segman R. (2017). Long-Term Immune Alterations Accompanying Chronic Posttraumatic Stress Disorder following Exposure to Suicide Bomb Terror Incidents during Childhood. Neuropsychobiology. 76, 130–135.

  6. Elhanati, S., Kanfi, Y., Varvak, A., Roichman, A., Carmel-Gross I., Barth S., Gibor G., and Cohen, H.Y. (2013). Multiple Regulatory Layers of SREBP1/2 by SIRT6. Cell Reports. 4(5), 905-912.

* co-first author

Preprints:

  1. Hajihassani O., Zarei M., Roichman A., Loftus A., …, Lund P.J., Rothermel L.D., Rabinowitz J.D. and Winter J.M. (2024). A Ketogenic Diet Sensitizes Pancreatic Cancer to Inhibition of Glutamine Metabolism. bioRxiv

Patents:

  1. Rabinowitz J.D., Roichman A. "Cancer treatment using PI3K inhibitors in combination with antibiotics or purified diets." Patent WO2024163039A1. Filed: November 28, 2023. Approved: August 8, 2024.

תאריך עדכון אחרון : 25/11/2025