פרופ' איתן אוקון

Recent Peer-reviewed Publications 

1.    CD8+ T cells exacerbate AD-like symptoms in mouse model of amyloidosis. Wang X, Campbell B, Bodogai M, McDevitt RA, Patrikeev A, Gusev F, Ragonnaud E, Kumaraswami K, Shirenova S, Vardy K, Alameh MG, Weissman D, Ishikawa-Ankerhold H, Okun E, Rogaev E, Biragyn A.Brain Behav Immun. 2024 Nov;122:444-455. doi: 10.1016/j.bbi.2024.08.045. Epub 2024 Aug 25.PMID: 39191349

2.    Unbiased analysis of spatial learning strategies in a modified Barnes maze using convolutional neural networks. Illouz T, Ascher LAB, Madar R, Okun E.Sci Rep. 2024 Jul 10;14(1):15944. doi: 10.1038/s41598-024-66855-8.PMID: 38987437.  

3.    Unraveling the molecular basis of cannabidiolic acid methyl Ester's anti-depressive effects in a rat model of treatment-resistant depression. Hen-Shoval D, Indig-Naimer T, Moshe L, Kogan NM, Zaidan H, Gaisler-Salomon I, Okun E, Mechoulam R, Shoval G, Zalsman G, Weller A.J Psychiatr Res. 2024 Jul;175:50-59. doi: 10.1016/j.jpsychires.2024.04.033. Epub 2024 Apr 24.PMID: 38704981

4.    Neuronal deletion of Gtf2i results in developmental microglial alterations in a mouse model related to Williams syndrome. Bar E, Fischer I, Rokach M, Elad-Sfadia G, Shirenova S, Ophir O, Trangle SS, Okun E, Barak B.Glia. 2024 Mar 7. 

5.    Unraveling the molecular basis of cannabidiolic acid methyl Ester's anti-depressive effects in a rat model of treatment-resistant depression. Hen-Shoval D, Indig-Naimer T, Moshe L, Kogan NM, Zaidan H, Gaisler-Salomon I, Okun E, Mechoulam R, Shoval G, Zalsman G, Weller A.J Psychiatr Res. 2024 Apr 24;175:50-59. doi: 10.1016/j.jpsychires.2024.04.033.

6.    Neural correlates of subjective cognitive decline in adults at high risk for Alzheimer's disease. Liat Ben-Ami, Ramit Ravona-Springer, Tsarfaty G, Raizman R, Shumacher A, Sharvit-Ginon I, Greenbaum L,  Bendlin BB, Okun E, Heymann A, Schnaider Beeri M, Livny A. Front Aging Neurosci. 2023 Feb 1;15:1067196.

7.    Early diagnosis and treatment of Alzheimer's disease by targeting toxic soluble Aβ oligomers. Maram Habashi, Suresh Vutla, Kuldeep Tripathi, Sudipta Senapati, Pradeep S Chauhan, Anat Haviv-Chesner, Michal Richman, Samia-Ait Mohand, Véronique Dumulon-Perreault, Ramakotaiah Mulamreddy, Eitan Okun, Jordan H Chill, Brigitte Guérin, William D Lubell and Shai Rahimipour. PNAS. 2022 Dec 6;119(49).  

8.    Sleeve Gastrectomy Reduces Glycemia but Does Not Affect Cognitive Impairment in Lean 5xFAD Mice.
Samuel I, Ben-Haroush Schyr R, Arad Y, Attali T, Azulai S, Bergel M, Halfon A, Hefetz L, Hirsch T, Israeli H, Lax N, Nitzan K, Sender D, Sweetat S, Okun E, Rosenmann H, Ben-Zvi D.Front Neurosci. 2022 Aug 11;16:937663

9.    COVID-19 Vaccination of Individuals with Down Syndrome-Data from the Trisomy 21 Research Society Survey on Safety, Efficacy, and Factors Associated with the Decision to Be Vaccinated. Hüls A, Feany PT, Zisman SI, Costa ACS, Dierssen M, Balogh R, Bargagna S, Baumer NT, Brandão AC, Carfi A, Chicoine BA, Ghosh S, Lakhanpaul M, Levin J, Lunsky Y, Manso C, Okun E, Real de Asua D, Rebillat AS, Rohrer TR, Sgandurra G, Valentini D, Sherman SL, Strydom A, On Behalf Of The Trisomy Research Society Covid-Initiative.Vaccines (Basel). 2022 Mar 29;10(4):530. 

10.    HCAR1-Mediated L-Lactate Signaling Suppresses Microglial Phagocytosis. Nicola R, Madar R, Okun E. Neuromolecular Med. 2022 Apr 11. doi: 10.1007/s12017-022-08710-5. 

11.    Integrative epigenomic and transcriptomic analyses reveal metabolic switching by intermittent fasting in brain. Ng GY, Sheng DPLK, Bae HG, Kang SW, Fann DY, Park J, Kim J, Alli-Shaik A, Lee J, Kim E, Park S, Han JW, Karamyan V, Okun E, Dheen T, Hande MP, Vemuganti R, Mallilankaraman K, Lim LHK, Kennedy BK, Drummond GR, Sobey CG, Gunaratne J, Mattson MP, Foo RS, Jo DG, Arumugam TV. Geroscience. 2022 Mar 31. 

12.    Physiology and pharmacology of amyloid precursor protein. Cho Y, Bae HG, Okun E, Arumugam TV, Jo DG.Pharmacol Ther. 2022 Feb 1;235:108122

13.    Induction of an effective anti-Amyloid-β humoral response in aged mice. Illouz T, Madar R, Hirsh T, Biragyn A and Okun E. Vaccine, July 2021, Aug 9;39(34):4817-4829

14.    Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome.
Illouz T, Biragyn A, Florencia Iulita M, Flores-Aguilar L, Dierssen M, De Toma I, Antonarakis S.E, Yu E, Herault Y, Potier M.C, Botté A, Roper R, Sredni B, London J, Mobley W, Strydom A and Okun E. on behalf of T21RS COVID-19 Initiative. Front. Immunol., 25 June 2021.

15.    Therapeutic B-cell depletion reverses progression of Alzheimer's disease. Kim K, Wang X, Ragonnaud E, Bodogai M,  Illouz T, DeLuca M,  McDevitt R.A,  Gusev F, Okun E, Rogaev E and Biragyn A. Nat Commun. 2021 Apr 12.

16.    Adult Hippocampal Neurogenesis: One Lactate to Rule Them All. Nicola R and Okun E. NeuroMolecular Medicine. 19 April 2021.

17.    Specific Susceptibility to COVID-19 in Adults with Down Syndrome.  Illouz T, Biragyn A, Frenkel-Morgenstern M, Weissberg O, Gorohovski A, Merzon E, Green I,  Iulita F, Flores-Aguilar L, Dierssen Sotos M, De Toma H, Lifshitz H, Antonarakis S.E, Yu E, Herault Y, Potier M.C, Botté A, Roper R, Sredni B, Sarid R, London J,  Mobley W, Strydom A and Okun E.  NeuroMolecular Medicine. 4 March 2021.

18.    High Intensity Functional Training: Molecular Mechanisms and Benefits. B. Zeev T and Okun E. NeuroMolecular Medicine. 01 January 2021.

19.    Maternal antibodies facilitate Amyloid-β clearance by activating Fc-receptor-Syk-mediated phagocytosis. Illouz T, Nicola R, Ben-Shuhan L, Madar R, Biragyn R and Okun E. Communications Biology. 12 March 2021. 

20.    Mild physical activity does not improve spatial learning in a virtual environment.
Okun E, B. Zeev T, Weiss I, Ashri S, Heled Y, Ketko I and Yanovich R. Front. Behav. Neurosci. 17 november 2020.

21.    The effects of High-Intensity Functional Training (HIFT) on spatial learning, visual pattern separation and attention span in adolescents. Okun E, Ben-Zeev T, Hirsh T, Weiss I and Gornstein M. Front. Behav. Neurosci. 21 August 2020.

22.    Food and Age: It Takes Two to Degenerate. Nicola R and Okun E. Front. Aging Neurosci., 26 June 2020.

23.    A modified Barnes maze for an accurate assessment of spatial learning in mice. 
Illouz T, Madar R and Okun E. J Neurosci Methods. Jan 2020.

24.    Lev-Vachnish Y, Cadury S, Rotter-Maskowitz A, Noa Feldman, Asael Roichman, Tomer Illouz, Alexander Varvak, Raneen Nicola, Ravit Madar, Eitan Okun. L-Lactate Promotes Adult Hippocampal Neurogenesis. Front Neurosci. 2019;13:403. 2019 May 24. 

25.    Tomer Illouz, Ravit Madar, Arya Biragyn and Eitan Okun. Restoring microglial and astroglial homeostasis using DNA immunization in a Down Syndrome mouse model. Brain, Behaviour and Immunity, 75, 163-180,  Jan 2019.