Prof. Eitan Okun
Basic and translational neuroimmunology: research of the interaction between the immune system and the nervous system.
B cells and cognitive decline: understanding the roles of B cells in cognitive decline related to Alzheimer’s disease and Down syndrome.
DNA vaccines: development of new vaccination strategies following advancement of neurodegenerative diseases.
Mother–fetus communication: research of mechanisms of transfer of cells and messages between the mother and the fetus and their effect on maternal cognitive decline after pregnancies with a fetus with Down syndrome.
Pre-clinical models: development and use of pre-clinical models for understanding neurodegenerative diseases and for testing new therapeutic approaches.
Research of aging and Down syndrome: understanding the connection between aging and Down syndrome in neurobiological and immunological aspects.
CV
Prof. Eitan Okun is a full professor and vice dean for research resource development in the Faculty of Life Sciences at Bar-Ilan University. He completed his bachelor's, master's, and doctorate degrees in life sciences and specialized in immunology at Bar-Ilan University. He conducted his postdoctoral research at the National Institute on Aging (NIH) in Baltimore, USA. During his academic career, he has gained rich experience in research and leading multidisciplinary projects, and has published dozens of articles in leading scientific journals.
Research
Neuroimmunology is the most rapidly advancing field of research in the study of brain diseases and particularly in Alzheimer’s disease. We are studying how immune cells interact with the brain during Aging, in Alzheimer’s disease and in individuals with Down syndrome. We also study the mechanistic link between pregnancy with a Down syndrome fetus and the elevated risk of maternal cognitive decline. The laboratory also develops vaccines against Alzheimer's disease, with the understanding that the best fight against neurodegenerative diseases, including Alzheimer's disease, is prevention.
Courses
Semester 1
Elective course "Biological Mechanisms of Learning and Memory", 80-3331-01.
The course is an asynchronous course open to students from all majors, in which we discuss the different types of learning, and the biological and molecular mechanisms that underlie memory formation.
The course is taught on Sundays between 2:00 PM and 4:00 PM
Semester 2
Compulsory course "Biochemistry B", 80-202-01
The course is a mandatory asynchronous course for students in the Faculty of Life Sciences, in which we discuss the regulation of energy production pathways in the body.
The course is taught on Sundays and Tuesdays between 12:00 PM and 2:00 PM.
Elective Course "Neurodegenerative Diseases of the Elderly", 80-978-01
The course is open to students from all majors, including neuroscience, biology, and gerontology, and discusses neurodegenerative diseases that affect elderly aged people.
The course is taught on Thursdays between 2:00 PM and 4:00 PM
Elective Course "Molecular mechanisms of neurodegenerative disease", 80-971-01 (ENGLISH)
The course is open to advanced students (M.Sc, Ph.D), who are interested in understanding the molecular mechanisms of pathologies that govern age-associated diseases including Alzheimer's disease, Parkinson's disease, Fronto-temporal dementia and Vascular dementia.
The course is taught - TBD
Publications
Recent Peer-reviewed Publications
1 Fruitman Davidi, A., Shirenova, S., Michaelovich, D., Benedetti, G., Shtrasberg, H., Shoval, I., Hauschner, H., Oz, G., Vardy, K., Hirsh, T., Madar, R., Stern, E. A., Rosenmann, H., Biragyn, A. & Okun, E. Dural ectopic lymphatic structures accumulate during aging and exhibit dysregulation in neurodegenerative diseases. Proc Natl Acad Sci U S A 122, e2425081122 (2025). https://doi.org:10.1073/pnas.2425081122
2 Wang, X., Campbell, B., Bodogai, M., McDevitt, R. A., Patrikeev, A., Gusev, F., Ragonnaud, E., Kumaraswami, K., Shirenova, S., Vardy, K., Alameh, M. G., Weissman, D., Ishikawa-Ankerhold, H., Okun, E., Rogaev, E. & Biragyn, A. CD8(+) T cells exacerbate AD-like symptoms in mouse model of amyloidosis. Brain Behav Immun 122, 444-455 (2024). https://doi.org:10.1016/j.bbi.2024.08.045
3 Illouz, T., Ascher, L. A. B., Madar, R. & Okun, E. Unbiased analysis of spatial learning strategies in a modified Barnes maze using convolutional neural networks. Sci Rep 14, 15944 (2024). https://doi.org:10.1038/s41598-024-66855-8
4 Hen-Shoval, D., Indig-Naimer, T., Moshe, L., Kogan, N. M., Zaidan, H., Gaisler-Salomon, I., Okun, E., Mechoulam, R., Shoval, G., Zalsman, G. & Weller, A. Unraveling the molecular basis of cannabidiolic acid methyl Ester's anti-depressive effects in a rat model of treatment-resistant depression. J Psychiatr Res 175, 50-59 (2024). https://doi.org:10.1016/j.jpsychires.2024.04.033
5 Bar, E., Fischer, I., Rokach, M., Elad-Sfadia, G., Shirenova, S., Ophir, O., Trangle, S. S., Okun, E. & Barak, B. Neuronal deletion of Gtf2i results in developmental microglial alterations in a mouse model related to Williams syndrome. Glia 72, 1117-1135 (2024). https://doi.org:10.1002/glia.24519
6 Ben-Ami, L., Ravona-Springer, R., Tsarfaty, G., Raizman, R., Shumacher, A., Sharvit-Ginon, I., Greenbaum, L., Bendlin, B. B., Okun, E., Heymann, A., Schnaider Beeri, M. & Livny, A. Neural correlates of subjective cognitive decline in adults at high risk for Alzheimer's disease. Front Aging Neurosci 15, 1067196 (2023). https://doi.org:10.3389/fnagi.2023.1067196
7 Samuel, I., Ben-Haroush Schyr, R., Arad, Y., Attali, T., Azulai, S., Bergel, M., Halfon, A., Hefetz, L., Hirsch, T., Israeli, H., Lax, N., Nitzan, K., Sender, D., Sweetat, S., Okun, E., Rosenmann, H. & Ben-Zvi, D. Sleeve Gastrectomy Reduces Glycemia but Does Not Affect Cognitive Impairment in Lean 5xFAD Mice. Front Neurosci 16, 937663 (2022). https://doi.org:10.3389/fnins.2022.937663
8 Nicola, R., Madar, R. & Okun, E. HCAR1-Mediated L-Lactate Signaling Suppresses Microglial Phagocytosis. Neuromolecular Med 24, 399-404 (2022). https://doi.org:10.1007/s12017-022-08710-5
9 Ng, G. Y., Sheng, D., Bae, H. G., Kang, S. W., Fann, D. Y., Park, J., Kim, J., Alli-Shaik, A., Lee, J., Kim, E., Park, S., Han, J. W., Karamyan, V., Okun, E., Dheen, T., Hande, M. P., Vemuganti, R., Mallilankaraman, K., Lim, L. H. K., Kennedy, B. K., Drummond, G. R., Sobey, C. G., Gunaratne, J., Mattson, M. P., Foo, R. S., Jo, D. G. & Arumugam, T. V. Integrative epigenomic and transcriptomic analyses reveal metabolic switching by intermittent fasting in brain. Geroscience 44, 2171-2194 (2022). https://doi.org:10.1007/s11357-022-00537-z
10 Huls, A., Feany, P. T., Zisman, S. I., Costa, A. C. S., Dierssen, M., Balogh, R., Bargagna, S., Baumer, N. T., Brandao, A. C., Carfi, A., Chicoine, B. A., Ghosh, S., Lakhanpaul, M., Levin, J., Lunsky, Y., Manso, C., Okun, E., Real de Asua, D., Rebillat, A. S., Rohrer, T. R., Sgandurra, G., Valentini, D., Sherman, S. L., Strydom, A. & On Behalf Of The Trisomy Research Society, C.-I. COVID-19 Vaccination of Individuals with Down Syndrome-Data from the Trisomy 21 Research Society Survey on Safety, Efficacy, and Factors Associated with the Decision to Be Vaccinated. Vaccines (Basel) 10 (2022). https://doi.org:10.3390/vaccines10040530
11 Habashi, M., Vutla, S., Tripathi, K., Senapati, S., Chauhan, P. S., Haviv-Chesner, A., Richman, M., Mohand, S. A., Dumulon-Perreault, V., Mulamreddy, R., Okun, E., Chill, J. H., Guerin, B., Lubell, W. D. & Rahimipour, S. Early diagnosis and treatment of Alzheimer's disease by targeting toxic soluble Abeta oligomers. Proc Natl Acad Sci U S A 119, e2210766119 (2022). https://doi.org:10.1073/pnas.2210766119
12 Cho, Y., Bae, H. G., Okun, E., Arumugam, T. V. & Jo, D. G. Corrigendum to "Physiology and pharmacology of amyloid precursor protein" [Pharmacology & Therapeutics Volume 235(2022) 108122. Pharmacol Ther 238, 108281 (2022). https://doi.org:10.1016/j.pharmthera.2022.108281
13 Cho, Y., Bae, H. G., Okun, E., Arumugam, T. V. & Jo, D. G. Physiology and pharmacology of amyloid precursor protein. Pharmacol Ther 235, 108122 (2022). https://doi.org:10.1016/j.pharmthera.2022.108122
14 Nicola, R. & Okun, E. Adult Hippocampal Neurogenesis: One Lactate to Rule Them All. Neuromolecular Med 23, 445-448 (2021). https://doi.org:10.1007/s12017-021-08658-y
15 Kim, K., Wang, X., Ragonnaud, E., Bodogai, M., Illouz, T., DeLuca, M., McDevitt, R. A., Gusev, F., Okun, E., Rogaev, E. & Biragyn, A. Therapeutic B-cell depletion reverses progression of Alzheimer's disease. Nat Commun 12, 2185 (2021). https://doi.org:10.1038/s41467-021-22479-4
16 Illouz, T., Nicola, R., Ben-Shushan, L., Madar, R., Biragyn, A. & Okun, E. Maternal antibodies facilitate Amyloid-beta clearance by activating Fc-receptor-Syk-mediated phagocytosis. Commun Biol 4, 329 (2021). https://doi.org:10.1038/s42003-021-01851-6
17 Illouz, T., Madar, R., Hirsh, T., Biragyn, A. & Okun, E. Induction of an effective anti-Amyloid-beta humoral response in aged mice. Vaccine 39, 4817-4829 (2021). https://doi.org:10.1016/j.vaccine.2021.07.023
18 Illouz, T., Biragyn, A., Iulita, M. F., Flores-Aguilar, L., Dierssen, M., De Toma, I., Antonarakis, S. E., Yu, E., Herault, Y., Potier, M. C., Botte, A., Roper, R., Sredni, B., London, J., Mobley, W., Strydom, A. & Okun, E. Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome. Front Immunol 12, 621440 (2021). https://doi.org:10.3389/fimmu.2021.621440
19 Illouz, T., Biragyn, A., Frenkel-Morgenstern, M., Weissberg, O., Gorohovski, A., Merzon, E., Green, I., Iulita, F., Flores-Aguilar, L., Dierssen, M., De Toma, I., Lifshitz, H., Antonarakis, S. E., Yu, E., Herault, Y., Potier, M. C., Botte, A., Roper, R., Sredni, B., Sarid, R., London, J., Mobley, W., Strydom, A. & Okun, E. Correction to: Specific Susceptibility to COVID-19 in Adults with Down Syndrome. Neuromolecular Med 23, 574-575 (2021). https://doi.org:10.1007/s12017-021-08695-7
20 Illouz, T., Biragyn, A., Frenkel-Morgenstern, M., Weissberg, O., Gorohovski, A., Merzon, E., Green, I., Iulita, F., Flores-Aguilar, L., Dierssen, M., De Toma, I., Lifshitz, H., Antonarakis, S. E., Yu, E., Herault, Y., Potier, M. C., Botte, A., Roper, R., Sredni, B., Sarid, R., London, J., Mobley, W., Strydom, A. & Okun, E. Specific Susceptibility to COVID-19 in Adults with Down Syndrome. Neuromolecular Med 23, 561-571 (2021). https://doi.org:10.1007/s12017-021-08651-5
21 Ben-Zeev, T. & Okun, E. High-Intensity Functional Training: Molecular Mechanisms and Benefits. Neuromolecular Med 23, 335-338 (2021). https://doi.org:10.1007/s12017-020-08638-8
22 Nicola, R. & Okun, E. Food and Age: It Takes Two to Degenerate. Front Aging Neurosci 12, 182 (2020). https://doi.org:10.3389/fnagi.2020.00182
23 Lugasi, L., Grinberg, I., Rudnick-Glick, S., Okun, E., Einat, H. & Margel, S. Designed proteinoid polymers and nanoparticles encapsulating risperidone for enhanced antipsychotic activity. J Nanobiotechnology 18, 149 (2020). https://doi.org:10.1186/s12951-020-00709-z
24 Illouz, T., Madar, R. & Okun, E. A modified Barnes maze for an accurate assessment of spatial learning in mice. J Neurosci Methods 334, 108579 (2020). https://doi.org:10.1016/j.jneumeth.2020.108579
25 Hagar, M., Roman, G., Eitan, O., Noam, B. Y., Abrham, Z. & Benjamin, S. A Tellurium-Based Small Immunomodulatory Molecule Ameliorates Depression-Like Behavior in Two Distinct Rat Models. Neuromolecular Med 22, 437-446 (2020). https://doi.org:10.1007/s12017-020-08603-5
26 Ben-Zeev, T., Weiss, I., Ashri, S., Heled, Y., Ketko, I., Yanovich, R. & Okun, E. Mild Physical Activity Does Not Improve Spatial Learning in a Virtual Environment. Front Behav Neurosci 14, 584052 (2020). https://doi.org:10.3389/fnbeh.2020.584052
27 Ben-Zeev, T., Hirsh, T., Weiss, I., Gornstein, M. & Okun, E. The Effects of High-intensity Functional Training (HIFT) on Spatial Learning, Visual Pattern Separation and Attention Span in Adolescents. Front Behav Neurosci 14, 577390 (2020). https://doi.org:10.3389/fnbeh.2020.577390
28 Lev-Vachnish, Y., Cadury, S., Rotter-Maskowitz, A., Feldman, N., Roichman, A., Illouz, T., Varvak, A., Nicola, R., Madar, R. & Okun, E. L-Lactate Promotes Adult Hippocampal Neurogenesis. Front Neurosci 13, 403 (2019). https://doi.org:10.3389/fnins.2019.00403
29 Illouz, T., Madar, R., Biragyn, A. & Okun, E. Restoring microglial and astroglial homeostasis using DNA immunization in a Down Syndrome mouse model. Brain Behav Immun 75, 163-180 (2019). https://doi.org:10.1016/j.bbi.2018.10.004
30 Shmueli, A., Shalit, T., Okun, E. & Shohat-Ophir, G. The Toll Pathway in the Central Nervous System of Flies and Mammals. Neuromolecular Med (2018). https://doi.org:10.1007/s12017-018-8515-9
31 Lavian, H., Loewenstern, Y., Madar, R., Almog, M., Bar-Gad, I., Okun, E. & Korngreen, A. Dopamine receptors in the rat entopeduncular nucleus. Brain Struct Funct 223, 2673-2684 (2018). https://doi.org:10.1007/s00429-018-1657-6
32 Griffioen, K., Mattson, M. P. & Okun, E. Deficiency of Toll-like receptors 2, 3 or 4 extends life expectancy in Huntington's disease mice. Heliyon 4, e00508 (2018). https://doi.org:10.1016/j.heliyon.2018.e00508
33 De Lorenzo, G., Ferrari, S., Cervone, F. & Okun, E. Extracellular DAMPs in Plants and Mammals: Immunity, Tissue Damage and Repair. Trends Immunol (2018). https://doi.org:10.1016/j.it.2018.09.006
34 Okun, E., Marton, D., Cohen, D., Griffioen, K., Kanfi, Y., Illouz, T., Madar, R. & Cohen, H. Y. Sirt6 alters adult hippocampal neurogenesis. PLoS One 12, e0179681 (2017). https://doi.org:10.1371/journal.pone.0179681
35 Lavian, H., Almog, M., Madar, R., Loewenstern, Y., Bar-Gad, I., Okun, E. & Korngreen, A. Dopaminergic Modulation of Synaptic Integration and Firing Patterns in the Rat Entopeduncular Nucleus. J Neurosci 37, 7177-7187 (2017). https://doi.org:10.1523/JNEUROSCI.0639-17.2017
36 Illouz, T., Madar, R., Griffioen, K. & Okun, E. A protocol for quantitative analysis of murine and human amyloid-beta1-40 and 1-42. J Neurosci Methods 291, 28-35 (2017). https://doi.org:10.1016/j.jneumeth.2017.07.022
37 Gross, A., Benninger, F., Madar, R., Illouz, T., Griffioen, K., Steiner, I., Offen, D. & Okun, E. Toll-like receptor 3 deficiency decreases epileptogenesis in a pilocarpine model of SE-induced epilepsy in mice. Epilepsia 58, 586-596 (2017). https://doi.org:10.1111/epi.13688
38 Betzer, O., Shilo, M., Opochinsky, R., Barnoy, E., Motiei, M., Okun, E., Yadid, G. & Popovtzer, R. The effect of nanoparticle size on the ability to cross the blood-brain barrier: an in vivo study. Nanomedicine (Lond) 12, 1533-1546 (2017). https://doi.org:10.2217/nnm-2017-0022
39 Illouz, T., Madar, R., Louzon, Y., Griffioen, K. J. & Okun, E. Unraveling cognitive traits using the Morris water maze unbiased strategy classification (MUST-C) algorithm. Brain Behav Immun 52, 132-144 (2016). https://doi.org:10.1016/j.bbi.2015.10.013
40 Illouz, T., Madar, R., Clague, C., Griffioen, K. J., Louzoun, Y. & Okun, E. Unbiased classification of spatial strategies in the Barnes maze. Bioinformatics 32, 3314-3320 (2016). https://doi.org:10.1093/bioinformatics/btw376
41 Illouz, T., Madar, R., Clague, C., Griffioen, K., Louzoun, Y. & Okun, E. Unbiased classification of spatial strategies in the Barnes maze. Bioinformatics (2016). https://doi.org:10.1093/bioinformatics/btw376
42 Madar, R., Rotter, A., Waldman Ben-Asher, H., Mughal, M. R., Arumugam, T. V., Wood, W. H., 3rd, Becker, K. G., Mattson, M. P. & Okun, E. Postnatal TLR2 activation impairs learning and memory in adulthood. Brain Behav Immun 48, 301-312 (2015). https://doi.org:10.1016/j.bbi.2015.04.020
43 Illouz, T. & Okun, E. No ECSIT-stential evidence for a link with Alzheimer's disease yet (retrospective on DOI 10.1002/bies.201100193). Bioessays 37, 5 (2015). https://doi.org:10.1002/bies.201400179
44 Feldman, N., Rotter-Maskowitz, A. & Okun, E. DAMPs as mediators of sterile inflammation in aging-related pathologies. Ageing Res Rev 24, 29-39 (2015). https://doi.org:10.1016/j.arr.2015.01.003
45 Barak, B., Feldman, N. & Okun, E. Cardiovascular Fitness and Cognitive Spatial Learning in Rodents and in Humans. J Gerontol A Biol Sci Med Sci 70, 1059-1066 (2015). https://doi.org:10.1093/gerona/glu162
46 Okun, E., Griffioen, K. J., Rothman, S., Wan, R., Cong, W. N., De Cabo, R., Martin-Montalvo, A., Levette, A., Maudsley, S., Martin, B., Arumugam, T. V. & Mattson, M. P. Toll-like receptors 2 and 4 modulate autonomic control of heart rate and energy metabolism. Brain Behav Immun 36, 90-100 (2014). https://doi.org:10.1016/j.bbi.2013.10.013
47 Okun, E. A heavy toll on the outcome of ischemic brain stroke. Exp Neurol 254, 166-167 (2014). https://doi.org:10.1016/j.expneurol.2014.02.002
48 Lee, J. H., Halperin-Sheinfeld, M., Baatar, D., Mughal, M. R., Tae, H. J., Kim, J. W., Carter, A., Lustig, A., Snir, O., Lavie, G., Okun, E., Mattson, M. P., Sredni, B. & Taub, D. D. Tellurium compound AS101 ameliorates experimental autoimmune encephalomyelitis by VLA-4 inhibition and suppression of monocyte and T cell infiltration into the CNS. Neuromolecular Med 16, 292-307 (2014). https://doi.org:10.1007/s12017-013-8277-3
49 Kim, W., Fiori, J. L., Shin, Y. K., Okun, E., Kim, J. S., Rapp, P. R. & Egan, J. M. Pancreatic polypeptide inhibits somatostatin secretion. FEBS Lett 588, 3233-3239 (2014). https://doi.org:10.1016/j.febslet.2014.07.005
50 Cheng, Y. L., Park, J. S., Manzanero, S., Choi, Y., Baik, S. H., Okun, E., Gelderblom, M., Fann, D. Y., Magnus, T., Launikonis, B. S., Mattson, M. P., Sobey, C. G., Jo, D. G. & Arumugam, T. V. Evidence that collaboration between HIF-1alpha and Notch-1 promotes neuronal cell death in ischemic stroke. Neurobiol Dis 62, 286-295 (2014). https://doi.org:10.1016/j.nbd.2013.10.009
51 Barak, B., Feldman, N. & Okun, E. Toll-like receptors as developmental tools that regulate neurogenesis during development: an update. Front Neurosci 8, 272 (2014). https://doi.org:10.3389/fnins.2014.00272
52 Kashiwaya, Y., Bergman, C., Lee, J. H., Wan, R., King, M. T., Mughal, M. R., Okun, E., Clarke, K., Mattson, M. P. & Veech, R. L. A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease. Neurobiol Aging 34, 1530-1539 (2013). https://doi.org:10.1016/j.neurobiolaging.2012.11.023
53 Griffioen, K. J., Rothman, S. M., Ladenheim, B., Wan, R., Vranis, N., Hutchison, E., Okun, E., Cadet, J. L. & Mattson, M. P. Dietary energy intake modifies brainstem autonomic dysfunction caused by mutant alpha-synuclein. Neurobiol Aging 34, 928-935 (2013). https://doi.org:10.1016/j.neurobiolaging.2012.07.008
54 Chigurupati, S., Mughal, M. R., Okun, E., Das, S., Kumar, A., McCaffery, M., Seal, S. & Mattson, M. P. Effects of cerium oxide nanoparticles on the growth of keratinocytes, fibroblasts and vascular endothelial cells in cutaneous wound healing. Biomaterials 34, 2194-2201 (2013). https://doi.org:10.1016/j.biomaterials.2012.11.061
55 Barak, B., Shvarts-Serebro, I., Modai, S., Gilam, A., Okun, E., Michaelson, D. M., Mattson, M. P., Shomron, N. & Ashery, U. Opposing actions of environmental enrichment and Alzheimer's disease on the expression of hippocampal microRNAs in mouse models. Transl Psychiatry 3, e304 (2013). https://doi.org:10.1038/tp.2013.77
56 Barak, B., Okun, E., Ben-Simon, Y., Lavi, A., Shapira, R., Madar, R., Wang, Y., Norman, E., Sheinin, A., Pita, M. A., Yizhar, O., Mughal, M. R., Stuenkel, E., van Praag, H., Mattson, M. P. & Ashery, U. Neuron-specific expression of tomosyn1 in the mouse hippocampal dentate gyrus impairs spatial learning and memory. Neuromolecular Med 15, 351-363 (2013). https://doi.org:10.1007/s12017-013-8223-4
57 Olkhanud, P. B., Mughal, M., Ayukawa, K., Malchinkhuu, E., Bodogai, M., Feldman, N., Rothman, S., Lee, J. H., Chigurupati, S., Okun, E., Nagashima, K., Mattson, M. P. & Biragyn, A. DNA immunization with HBsAg-based particles expressing a B cell epitope of amyloid beta-peptide attenuates disease progression and prolongs survival in a mouse model of Alzheimer's disease. Vaccine 30, 1650-1658 (2012). https://doi.org:10.1016/j.vaccine.2011.12.136
58 Okun, E., Barak, B., Saada-Madar, R., Rothman, S. M., Griffioen, K. J., Roberts, N., Castro, K., Mughal, M. R., Pita, M. A., Stranahan, A. M., Arumugam, T. V. & Mattson, M. P. Evidence for a developmental role for TLR4 in learning and memory. PLoS One 7, e47522 (2012). https://doi.org:10.1371/journal.pone.0047522
59 Halperin-Sheinfeld, M., Gertler, A., Okun, E., Sredni, B. & Cohen, H. Y. The Tellurium compound, AS101, increases SIRT1 level and activity and prevents type 2 diabetes. Aging (Albany NY) 4, 436-447 (2012). https://doi.org:10.18632/aging.100468
60 Griffioen, K. J., Wan, R., Brown, T. R., Okun, E., Camandola, S., Mughal, M. R., Phillips, T. M. & Mattson, M. P. Aberrant heart rate and brainstem brain-derived neurotrophic factor (BDNF) signaling in a mouse model of Huntington's disease. Neurobiol Aging 33, 1481 e1481-1485 (2012). https://doi.org:10.1016/j.neurobiolaging.2011.11.030
61 Cheng, A., Wan, R., Yang, J. L., Kamimura, N., Son, T. G., Ouyang, X., Luo, Y., Okun, E. & Mattson, M. P. Involvement of PGC-1alpha in the formation and maintenance of neuronal dendritic spines. Nat Commun 3, 1250 (2012). https://doi.org:10.1038/ncomms2238
Last Updated Date : 23/03/2026
