Cellular and Developmental Biology

  1. Molecular neuroscience and neuroendocrinology using the zebrafish model
  2. Imaging of single molecules, organelles and cells in live animal
  3. The mechanism of sleep and sleep disorders
  4. The cause and treatments for genetic neurological disorders such as Fragile X syndrome and thyroid hormone-deficiency

Prof. Appelbaum Lior

  1. Biochemical mechanisms involved in sperm preparation for fertilization
  2. Signal transduction processes that mediate sperm capacitation and the acrosome reaction
  3. Biochemical mechanisms involved in preventing spontaneous acrosome reaction
  4. Signal transduction processes involved in sperm motility regulation
  5. Developing diagnostic methods for evaluation of infertility in man
  6. Developing treatment for man infertility.

Prof. Breitbart Haim

  1. The molecular base of aging, the role of deacetylases in life longevity.
  2. The molecular pathways that regulate the response for caloric restriction.
  3. The molecular and cellular biology of sirtuin deacetylases.
  4. Isolating new proteins that regulate longevity in mammals.

Prof. Cohen Haim

  1.  The MEIG1 protein - fertility and involvement in genome integrity and tumor development
  2. The PIM2 kinase as an Oncogene and a Tumor suppressor.
  3. The transcription factor ATCE1 - Paternal donation to embryonic development.

Prof. Don Jeremy (Rami)

  1. How the genome is folded in 3D in plant cells and how this folding is linked to gene regulation
  2. Identifying novel regulatory elements and gene regulatory networks in the plant genome
  3. Mechanisms of positive and negative transcriptional response to a single transcription factor.
  4. Rapid transcriptional response of immune cell to steroid hormones
  5. How the genome is organized in 3D during cellular differentiation and cancer progression.
  6. Identifying transcription factors driving tumorigenic transformation in breast cancer.

Dr. Hakim Ofir

  1.  Developing genome editing as curative therapy for genetic diseases
  2. Developing genome editing as a tool for cancer immunotherapy
  3. Improving the specificity, toxicity and safety of gene therapy by CRISPR-Cas9 system
  4. Manipulating the choice of DNA repair pathways during genome editing process
  5. Study the relationship between epigenome structure and genome editing outcomes in human hematopoietic stem and progenitor cells

Dr. Hendel Ayal

  1.  Deciphering the Genetic Code of Aging.
  2. How to maintain protein folding with age.
  3. The effect of longevity pathways on stress responses and age-related diseases, focusing on neurodegenerative diseases.

Prof. Henis-Korenblit Sivan

  1.  Molecular analysis of transcriptional regulation of key developmental genes
  2. Understanding the importance of promoter composition in transcription
  3. Studying the protein factors involved in recruitment of the transcription machinery
  4. Transcriptional regulation of developmental gene networks in Drosophila
  5. Rational design of synthetic promoters for enhanced gene expression
  6. Bioinformatics analyses of the regulation of gene expression in diverse organisms

Prof. Juven-Gershon Tamar

  1. Photo-dynamic therapy of cancer cells by ALA-PDT 
  2. Photo-diagnosis of brain tumors by ALA (protoporhyrin IX)
  3. Photo-dynamic killing of antibiotic resistant bacteria by photo-sensitizes

Prof. Malik Zvi

  1.  Nek kinases involvement in the development of Polycystic kidney disease
  2. The influence of inducible Nek7 ablation on the dynamics of the cell cycle.
  3. The cellular roles of Codanin-1 gene implicated in congenital dyserythropoietic anemia

Dr. Motro Benny

  1. Following mRNAs in living cells using high-resolution fluorescence microscopy
  2. Examining gene expression and transcription of single alleles in living cells in real-time
  3. Studying RNA processing factors in time and nuclear space
  4. Following long non-coding RNAs in the nucleus under normal and stress conditions
  5. Tracking the exit of mRNAs from the nucleus and through the nuclear pore using super-resolution microscopy and live-cell imaging
  6. Following signal transduction pathways that induce the activation of genes expressed in normal and cancer cells
  7. Examining stress-induced cytoplasmic granules and understanding their function in cells

Prof. Shav-Tal Yaron

  1. Cell division and cytokinesis in normal and malignant mammalian cells
  2.  E2F-APC/C interface in proliferating cells 
  3. Protein dynamics and post-translational modifications in cells and cell-free systems; basic and translational research
  4. Optical flow cytometry for cell cycle, cell growth and cell size research

Dr. Tzur Amit

  1. Disease modeling by human pluripotent stem cells
  2. Embryonic kidney development
  3. The effect of Lin28 on human and mouse embryonic development

Dr. Urbach Achia

  1. Evolution of the Tenerurin gene family in Metazoans.
  2. Axonal pathfinding in the Drosophila visual system.
  3. Signaling mechanisms of Teneurin proteins.

Prof. Wides Ron

  1. Inheritance of resistance against downy mildew in cucumber.
  2. Breeding cucumber for disease resistance.
  3. Transfer of resistance genes against downy mildew, Fusarium wilt and cold stress from wild basil to sweet basil.
  4. Aromatics and tolerance of basil against white fly Bemisia tabaci
  5. Cannabinoids profiling in cannabis strains: genetics and environment.
  6. Chemical mutagenesis of cannabis.
  7. Transformation of cannabis.
  8. Chemical control of oomycete plant diseases.
  9. Phenotyping and genotyping of the Irish famine disease of potato.
  10. Eradication of fungal molds in cannabis inflorescences.
Prof. Cohen Yigal