Faculty of Life Sciences, Tel-Aviv University, Tel- Aviv, Israel
"Research Program for Excellence" of the Faculty of Life Sciences
1991-1993 M.Sc. (Cum Laude)
Dept. of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
Dept. of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
2000-2005 Postdoctoral Fellow
Division of Biological Sciences, University of California, San Diego
2015- present, Associate Professor, The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
2009-2015, Senior Lecturer, The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
2005-2009, Assistant Project Scientist, Division of Biological Sciences, University of California, San Diego.
Molecular Studies of Transcription and Regulation of Developmental Genes
We study the molecular basis of the fascinating process by which our different body parts are formed during development.
The regulation of gene transcription is critical for the proper development and growth of an organism. The function of these genes is also crucial for us as adults; in the unfortunate event of malfunction, the end result might be cancer, such as leukemia.
Control elements that are embedded in the DNA sequences of genes are responsible for proper development. We study these DNA sequence elements and how they control different genes. Our analysis is important for understanding the regulation of development and complex systems.
We focus on the core promoter,whichis generally defined to be the DNA region that directs the accurate initiation of transcription by RNA polymerase II. In the past, the core promoter has often been presumed to be a generic entity that functions by a single universal mechanism. Recent findings reveal that there is widespread diversity in core promoter structure and function.We have embarked on the identification of biological functions of core promoter motifs and the identification of core promoter-specific activators.
Our goal is to understand the complex regulation of eukaryotic gene expression. We focus on the uniquecontribution of the core promoter to transcriptional regulation of gene networks.
In our research, we use the fruit fly (scientifically known as Drosophila melanogaster), as our model organism. The fruit fly has been used as an excellent model for genetics and developmental biology for many years. Strikingly, at the molecular level, there is remarkable similarity between humans and flies. Practically, this means that studying the regulation of development in the fly can teach us a lot about the regulation in humans.
In our lab we combine methodologies of molecular biology, biochemistry, cell biology, bioinformatics and developmental biology.
80-558 Transcriptional Regulation in Eukaryotes
80-242 Molecular Biology and Genetic Engineering
80-490 "Psagot" (combined B.Sc.-M.Sc. program for excellent students) 3rd year B.Sc. Seminar
80-994 "Psagot" (combined B.Sc.-M.Sc. program for excellent students) M.Sc. Research Seminar