Prof. Galit Shohat-Ophir

עברית Tell a Friend
Associate Professor
Institute of Nanotechnology and Advanced Materials, Building 206, 6th floor, Room C-663
Research Categories


Animals execute many different behaviors in the course of their lives with the goal of surviving and reproducing; they find food and mates, defend themselves and in many cases care for their offspring or other relatives. When these behaviors involve the interaction with other members of the same species they are considered social interaction. Living in a social environment requires perception of a socially relevant sensory stimulus, representation of this information in the brain, and integration of the stimulus with other relevant cues. Thus, social experiences can induce long-lasting changes in neural circuit function and ultimately altered behavior.

My research interest is to define the principles by which social interactions among individuals produce specific changes in the brain that lead to modification of behavior. In particular I am interested in identifying the molecular signature of social experience within defined subset of neuronal populations. We are exploring this question using reproductive behavior, possibly the most important event in an animal’s life, using Drosophila melanogaster as a model system.

  1. G. Shohat-Ophir, K R. Kaun, R. Azanchi, H. Mohammed, and U. Heberlein Sexual deprivation increases ethanol intake in Drosophila. (2012) Science. 335:1351-5. (Recommended by Faculty of 1000 as a must to read).

  2. Guenebeaud C, Goldschneider D, Castets M, Guix C, Chazot G, Delloye-Bourgeois C, Eisenberg-Lerner A, Shohat G, Zhang M, Laudet V, Kimchi A, Bernet A, Mehlen P. (2010) The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase. Mol Cell. 40: 863-876.

  3. Corl AB, Berger KH, Ophir-Shohat G, Gesch J, Simms JA, Bartlett SE, Heberlein U. (2009) Happyhour, a Ste20 family kinase, implicates EGFR signaling in ethanol-induced behaviors. Cell. 137(5):949-60.

  4. Gozuacik D, Bialik S, Raveh T, Mitou G, Shohat G, Sabanay H, Mizushima N, Yoshimori T, and Kimchi A. (2008) DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagoc cell death. Cell Deah Differ. 15:1875-86.

  5. Citri A, Harari D, Shohat G, Ramakirsham P, Gan J, Eisenstein M, Kimchi A, Wallach D, Pietrokovski A and Yarden A. (2006) Hsp90 recognizes a common surface on client kinases. J Biol Chem. 19;281(20):14361-9.

  6. Shani G, Marash L, Gozuacik D, Bialik S, Teitelbaum L, Shohat G, Kimchi A. (2004) Death-associated protein kinase phosphorylates ZIP kinase, forming a unique kinase hierarchy to activate its cell death functions. Mol. Cell Biol. 24:8611-26.

  7. Toledano-Katchalski H, Kraut J, Sines T, Granot-Attas S, Shohat G, Gil-Henn H, Yung Y, Elson A. (2003) Protein tyrosine phosphatase epsilon inhibits signaling by mitogen-activated protein kinases. Mol. Cancer Res. 7:541-50.

  8. Shohat G, Spivak-Kroizman T, Eisenstein M, Kimchi A. (2002) The regulation of death-associated protein (DAP) kinase in apoptosis. Eur. Cytokine Netw. 13:398-400.

  9. Shohat G, Shani G, Eisenstein M, Kimchi A. (2002) The DAP-kinase family of proteins: study of a novel group of calcium-regulated death-promoting kinases. Biochim. Biophys. Acta.1600:45-50.

  10. Henis-Korenblit S, Shani G, Sines T, Marash L, Shohat G, Kimchi A. (2002) The caspase-cleaved DAP5 protein supports internal ribosome entry site-mediated translation of death proteins. Proc. Natl. Acad. Sci. USA. 99:5400- 5.

  11. Shohat G, Spivak-Kroizman T, Cohen O, Bialik S, Shani G, Berrisi H, Eisenstein M, Kimchi A. (2001) The pro- apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation- based mechanism. J. Biol. Chem. 276:47460-7.

  12. Seluanov A, Gorbunova V, Falcovitz A, Sigal A, Milyavsky M, Zurer I, Shohat G, Goldfinger N, Rotter V. (2001) Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53. Mol. Cell Biol. 21:1552-64.