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Prof. Yeshayahu Nitzan

Associate Professor
Telephone
Email
nitzay@biu.013.net.il
Office
Lauterman Building (109), Rooms 58 (office); 59-60 (lab)
CV

Education

1961-1965, BSc (cum laude), Microbiology and Biochemistry, Bar-Ilan University, Ramat-Gan, Israel

1966-1968, MSc (summa cum laude), Microbiology, Bar-Ilan University, Ramat-Gan, Israel

1968-1972, PhD, Biochemistry, Dept. of Chemical Immunology, The Weizmann Institute of Science, Rehovot, Israel

1974-1976, POSTDOCTORAL FELLOW, Research on variants of chloramphenicol acetyltransferases, Dept. of Biochemistry, University of Leicester, England

 

Positions

1989-present, ASSOCIATE PROFESSOR, Microbiology – Photosensitization, porin channels, The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University

1992-1993, SABBATICAL, Microbial Diseases and Photosensitization, Microbial Disease Research Laboratory, Veterans Administration Wadsworth Medical Center, UCLA

1989, ASSOCIATE PROFESSOR, Medical Microbiology and Chemotherapy for medical students, Dept. of Human Microbiology, Tel-Aviv University

1986-1987, SABBATICAL, Microbiology, Dept. of Medical Microbiology, University of London, The London Hospital Medical College, England

1980-1989, SENIOR LECTURER, Microbiology, Dept. of Life Sciences, Bar-Ilan University

1977-1993, Research and development projects advisOr (part-time), Medical Microbiology Clinical Laboratories, Meir Hospital, Kfar Saba

1976-1980, LECTURER, Microbiology, Dept. of Life Sciences, Bar-Ilan University

 

Academic Administrative Positions

2008-2010, CHAIRMAN of the Committee for Evaluation of the Faculty of Life Sciences for the National Council for Higher Education (Malag)

2003-2007, HEAD, Optometry Program, Bar-Ilan University

2002-2003, DEPUTY HEAD, Optometry Program, Bar-Ilan University

1998-2002, DEPARTMENT HEAD, Cellular and Medical Biology, Faculty of Life Sciences, Bar-Ilan University

1996-1998, DEPUTY HEAD – as advisor for establishing new faculty, Dept. of Life Sciences, Bar-Ilan University

1990-1991, CHAIRMAN AND ORGANIZER, Annual Meeting of the Israel Society for Microbiology

1988-1990, HEAD OF DEPARTMENT, Dept. of Life Sciences, Bar-Ilan University

1982-1985, DEPUTY HEAD, Dept. of Life Sciences, Bar-Ilan University

 

Public Scientific Activities

2005-2007, MEMBER, Control Committee of the Israel Society for Microbiology

2002-present, Member, National Council for Clinical Laboratories, Ministry of Health

2001-2006, Member, Educational Program Committee, Bar-Ilan University

2000-2002, Member, Committee for Stipends from the President’s Fund to excellent Ph.D. students

1998-2002, Head of the Educational Program Committee, Faculty of Life Sciences, Bar-Ilan University

1997-2001, SECRETARY, Israel Society for Microbiology

1996-2001, MEMBER, General Committee of the Israel Society for Microbiology

1996-1998, MEMBER, Faculty of Natural Sciences Committee for Additional Work, Bar-Ilan University

1996-1998, MEMBER, Faculty of Natural Sciences Advisory Sub-Committee for Graduate Students, Bar-Ilan University

1994-2004, MEMBER, Educational Program of Bat-Yam College

1994-2004, MEMBER, Municipal Educational Committee Bat-Yam

1991-1993, MEMBER, General Committee of the Israel Society for Microbiology

1990-2000, MEMBER, Educational Committee of the National Religious Party, Bat-Yam Branch

1986-1997, MEMBER, Interviewing Committee for Acceptance to the Student Dormitories, Bar-Ilan University

1984-1997, MEMBER, Religious Council of Bat-Yam

 

Awards

1974-1975, Postdoctoral grant of the British Royal Society

1976, Medical Research Council grant for postdoctorants

1977, Recipient of the Bat-Sheva Rothschild Award

1990-2010, E. Rappaport Chair of Medical Microbiology

 

 

 

Research

Medical Microbiology 

Photodynamic therapy by exogenic porphyrins displays potent cytotoxic activity against Gram positive bacteria. For Gram-negative bacteria, photosensitization is possible only with a positively-charged porphyrin. The photodynamic effects on the viability of bacteria and yeasts are very efficient. Mechanisms of photoinactivation and target sites in the bacterial cell are investigated. Examination by electron microscopy of damage in intracellular structures, as well as the changes in the elemental content of the bacterial cells, is studied.

Photodynamic therapy by endogenic porphyrins is based on the ability of d-amino levulinic acid (ALA) to induce endogenic synthesis of porphyrins. Upon illumination, photoinactivation occurs, followed by intracellular damages and changes in the elemental content. The role of the endogenic porphyrins in the photodynamic process is studied.

Structure and function of pore-forming proteins isolated from the outer membrane of Gram negative bacterial. The penetration ability of sugars, amino acids and antibiotics through these porins is investigated. Sequencing of the proteins and isolation of the analogous genes are also investigated. Prediction of the secondary structure and finding the sequences of the loops that are very important for the pathogenic behavior of the microorganism, are investigated.

 

Other Research Subjects

1) Adhesion of Coagulase Negative Staphylococci to bones

2) Adherence mechanisms of bacteria to bones and its prevention using exogenous photosensitizers

3) Isolation, cultivation and molecular identification of bacteria that adhered to coral's mucus

4) Genetic characterization of bacteria causing infectious disease in the elderly population

5) Survival of viruses, bacteria and parasites in various sources of water

6) Nanoparticles and their use as bacteriocides.

 

Current Research Group Dr. Izabella Pechatnikov, Research Associate

Sassi Sigawi, PhD student

Esther Michael-Levi, PhD student

Marina Taran, MSc student

Nissim Swisa, PhD student

Mina Gutterman, PhD student

Neta-Li Buaron, MSc student

Sivan Sassi, MSc student

 

 

 

  

Last Updated Date : 24/05/2016