Prof. Shay Ben-Aroya

Institute of Nanotechnology and Advanced Materials, Building 206, Room B-840

Personal details:

Date of birth: October 17, 1968

Place of birth: Israel

Military Service (1987-1994)- Graduate of the Israeli Naval Academy-Released as a Major

Academic background:

October 2009-present: Senior lecturer

Bar-Ilan University

Ramat-Gan Israel

2005-July 2009:  Post-doctoral Fellow

University of British Columbia,

Michael Smith Laboratories,

Vancouver, BC, Canada

PI: Dr. Philip A. Hieter

Research: “Identifying and exploiting the underlying molecular defects leading to Chromosome Instability in Cancer”

1999-2003: PhD.

Tel-Aviv University

Dept. of Molecular Micro and Biotech

PI: Professor Martin Kupiec

Thesis Title: “Characterization of factors involved in the maintenance of genome stability in the yeast Saccharomyces Cerevisiae

1997-1999: MSc.

Tel-Aviv University

Dept. of Molecular Micro and Biotech

PI: Professor Martin Kupiec

Thesis Title: “Mutants of Saccharomyces cerevisiae that show  increased levels of recombination between repeated sequences”

1994 –1997: BSc.

Biology Tel-Aviv University, Tel-Aviv, Israel



Our laboratory uses the baker yeast Saccharomyces cerevisiae as a model system for understanding Genome stability, Cancer and Protein Quality Control. Please refer to our lab website ( in order to learn more about our research.



Selected publications (since 2010):

  • Identification of exceptionally potent adenosine deaminases RNA editors from high body temperature organisms. Adi Avram-Shperling, Eli Kopel, Orshay Gabay, Amit Ben-David, Sarit Karako-Lampert, Joshua J.C. Rosenthal, Erez Y. Levanon, Eli Eisenberg* and Shay Ben-Aroya1. 2022, Under revisions, PLOS GENETICS


  • Reversal of histone H2B mono-ubiquitination is required for replication stress recovery. Hadar Tzemach Korenfeld*, Adi Avram Shperling*, Yifat Zukerman, Anais Iluz, Hanna Boocholez, Lilach Ben-Shimon and Shay Ben-Aroya. DNA Repair (Amst). 2022 Aug 18;119:103387


  • Inherited retinal diseases: Linking genes, disease-causing variants, and relevant therapeutic modalities. Schneider N, Sundaresan Y, Gopalakrishnan P, Beryozkin A, Hanany M, Levanon EY, Banin E, Ben-Aroya S, Sharon D. Prog Retin Eye Res. 2022 Jul;89:101029. doi: 10.1016/j.preteyeres.2021.101029. Epub 2021 Nov 25. Review.
  • Spatial organization of proteasome aggregations regulates proteasome subunits homeostasis. Ofri Karmon, and Shay Ben-Aroya. Front Mol Biosci. 2020 Jan 9;6:150.


  • Regulation of the Anaphase Promoting Complex/Cyclosome by the Degradation of its Unassembled Catalytic Subunit, Apc11. Volpe M, Levinton N, Rosenstein N, Prag G, Ben-Aroya S. FASEB J. 2019 Sep;33(9):9752-9761.


  • Fe-S cluster coordination of the chromokinesin KIF4A alters its subcellular localization during mitosis. Ben-Shimon L, Paul VD, David-Kadoch G, Volpe M, Stümpfig M, Bill E, Mühlenhoff U, Lill R, Ben-Aroya S. J Cell Sci. 2018 Jun 27;131(12).


  • A-to-I RNA Editing: An Overlooked Source of Cancer Mutations. Ben-Aroya S*, Levanon EY*. Cancer Cell. 2018 May 14;33(5):789-790.*Co-corresponding authors





  • Lee Zeev Peters*, Ofri Karmon*, Rotem Hazan , and Ben-Aroya S. The protein quality control machinery regulates its misassembled proteasome subunits, and distinguishes them from proteasome storage granules. PLOS Genet. (2015)






  • Fridman Y, Palgi N, Dovrat D, Ben-Aroya S, Hieter P, Aharoni A.Subtle alterations in PCNA-partner interactions severely impair DNA replication and repair. PLoS Biol. (2010)
  • Parnas O, Zipin-Roitman A, Pfander B, Liefshitz B, Mazor Y, Ben-Aroya S, Jentsch S, Kupiec M. Elg1, an alternative subunit of the RFC clamp loader, preferentially interacts with SUMOylated PCNA. EMBO J. Aug 4;29(15):2611-22. (2010)


  • Shay Ben-Aroya, Neta Agmon, Karen Yuen, Kirk McManus, Martin Kupiec, and Philip Hieter. Proteasome nuclear activity affects chromosome stability by controlling the turnover of Mms22, a protein important for DNA repair.  PLoS Genetics. (2010)


Last Updated Date : 10/11/2022