- Investigating the molecular mechanisms regulating the immune response by using advanced molecular imaging technologies.
- Developing novel immunotherapeutic approaches to treat cancer.
- Studying primary immunodeficiencies and developing therapeutic strategies.
- Boosting natural killer cell immune response in pathologies.
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Prof. Barda-Saad Mira
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- Understanding how eukaryotic cells keep their genome stable
- How eukaryotic cells distinguish properly folded from misfolded proteins, to prevent proteotoxic stress, and neurodegenerative diseases.
- Molecular genetics and cell biology of the model system, the yeast Saccharomyces cerevisiae.
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Prof. Ben-Aroya Shay
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- Development of novel immunotherapies for cancer and viral diseases.
- Genetic engineering and editing of immune cells to express chimeric receptors (CAR-T and CCR-T cells).
- Utilization of the tumor environment to enhance anti-tumor immunity.
- Study of immune exhaustion mechanisms and their inhibition to improve immunity.
- Development of theranostic approaches and use of antibody-targeted nanoparticles (in collaboration with Prof. Popovtzer - Faculty of Engineering).
- Characterization of the anti-tumor immune response and identification of novel immune targets.
- Enhancement of T-cell motility to tumors and metastasis.
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Prof. Cohen Cyrille
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- The molecular base of aging, the role of deacetylases in life longevity.
- The molecular pathways that regulate the response for caloric restriction.
- The molecular and cellular biology of sirtuin deacetylases.
- Isolating new proteins that regulate longevity in mammals.
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Prof. Cohen Haim
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- The T-cell Repertoire
- Single-cell RNA sequencing
- Networks in Cancer Genomics
- Predicting drug response through cancer genomics
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Prof. Efroni Sol
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- Elucidation of the molecular mechanism that mediates the effects of E2F on cell fate and intracellular signaling.
- Studying the mechanisms by which E2F1 sensitizes cells to chemotherapeutic treatments.
- Studying the crosstalk between E2Fs and signal transduction pathways.
- Isolation and characterization of novel E2F-regulated genes that affect autophagy. Elucidating the role of E2Fs in the regulation of autophagy.
- Identification of novel molecular links between E2F1 and the tumor suppressor p53.
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Prof. Ginsberg Doron
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- How the genome is folded in 3D in plant cells and how this folding is linked to gene regulation
- Identifying novel regulatory elements and gene regulatory networks in the plant genome
- Mechanisms of positive and negative transcriptional response to a single transcription factor.
- Rapid transcriptional response of immune cell to steroid hormones
- How the genome is organized in 3D during cellular differentiation and cancer progression.
- Identifying transcription factors driving tumorigenic transformation in breast cancer.
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Dr. Hakim Ofir
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- Models and simulations of the dynamics of the development of T and B lymphocytes, the rearrangement of B cell and T cell antigen receptor genes, and subsequent selection, which is based on receptor-ligand interactions.
- Models for the development of the natural killer (NK) cell repertoire, from receptor gene expression to selection of functional, non-harmful cells.
Studies of the competition between B lymphocyte clones during the humoral immune response, the process of hypermutation, and the creation of memory cells, including the explanation of the phenomenon of repertoire shift, isotype switch, and graph-theoretical analysis of B lymphocyte immunoglobulin gene phylogenetic trees.
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Prof. Mehr Ramit
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- Studying the reprogrammed metabolic and enrgy generation systems of cancer cells.
- Studying the regulatory role of the FerT kinase, which is solely present in the mitochondria of sperm and cancer cells.
- Development of new anti-cancer drugs, which selectively target the reprorammed mitochondria of cancer cells in general, and metastatic malignant cells in particular.
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Prof. Nir Uri
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- Structural biology - X-ray crystallography
- Drug design
- Axon guidance - the Slit-Robo signaling system
- Molecular basis for human brain evolution
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Prof. Opatowsky Yarden
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- Following mRNAs in living cells using high-resolution fluorescence microscopy
- Examining gene expression and transcription of single alleles in living cells in real-time
- Studying RNA processing factors in time and nuclear space
- Following long non-coding RNAs in the nucleus under normal and stress conditions
- Tracking the exit of mRNAs from the nucleus and through the nuclear pore using super-resolution microscopy and live-cell imaging
- Following signal transduction pathways that induce the activation of genes expressed in normal and cancer cells
- Examining stress-induced cytoplasmic granules and understanding their function in cells
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Prof. Shav-Tal Yaron
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- Prevention of Chemotherapy-Induced Hematopoietic Damage by Oral Administration of SAS : Potential Role of VLA-4 Inactivation by the Compound
- Effect of the Tellurium compound SAS on PD-L1 Expression in AML: Mechanism of Action and Clinical Aspects
- Effect of the Tellurium Compound SAS on the Reciprocal leukemia- Stroma VLA-4-Dependent Activation of NF-kB Mediated Chemoresistance
- Effect of Tellurium Compound AS101 on PD-L1 Expression on Human NSCLC : Mechanism of Action and Correlation with Clinical Results in NSCLC Patients
- Effect of the Tellurium Compound SAS on PD-L1 Expression on Human and Murine Melanoma: Mechanism of Action and Clinical Aspects
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Prof. Shredni Benjamin
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- Mechanisms of host-microbiome communications
- Intestinal neuro-immune-microbiome interactions
- Effects of the gut microbiota on autoimmunity and cancer
- Computational biology / bioinformatics – analysis of host and microbiome transcriptomics
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Dr. Yissachar Nissan
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