Genomics & Computational Biology Seminar

עברית
03/01/2013 - 12:00Add To Calendar 2013-01-03 12:00:00 2013-01-03 12:00:00 סמינר גנומיקה וביולוגיה חישובית Genomics & Computational Biology Seminar Date and Time: Thursday, January 3, 2013, at 12:00 Place: The Nano building (206) seminar room on the 9th floor Speaker: Danny Barash, Department of Computer Science, Ben-Gurion University of the Negev Title: Fragment-Based Design of RNA Sequences and Detection of RNA Switches The inverse RNA folding problem for designing sequences that fold into a given RNA secondary structure was introduced in the early 1990's in Vienna. Using a coarse-grain tree graph representation of the RNA secondary structure, we extended the inverse RNA folding problem to include constraints such as thermodynamic stability and mutational robustness, deveoping a program called RNAexinv. Furthermore, we propose a fragment-based design approach of RNA sequences that can be useful to practitioners in a variety of biological applications. In this shape-based design approach, specific RNA structural motifs with known biological functions are strictly enforced while others can possess more flexibility in their structure in favor of preserving physical attributes and additional constraints.     הפקולטה למדעי החיים webls@mail.biu.ac.il Asia/Jerusalem public

Genomics & Computational Biology Seminar

Date and Time: Thursday, January 3, 2013, at 12:00

Place: The Nano building (206) seminar room on the 9th floor

Speaker: Danny Barash, Department of Computer Science, Ben-Gurion University of the Negev

Title: Fragment-Based Design of RNA Sequences and Detection of RNA Switches

The inverse RNA folding problem for designing sequences that fold into a given RNA secondary structure was introduced in the early 1990's in Vienna. Using a coarse-grain tree graph representation of the RNA secondary structure, we extended the inverse RNA folding problem to include constraints such as thermodynamic stability and mutational robustness, deveoping a program called RNAexinv. Furthermore, we propose a fragment-based design approach of RNA sequences that can be useful to practitioners in a variety of biological applications. In this shape-based design approach, specific RNA structural motifs with known biological functions are strictly enforced while others can possess more flexibility in their structure in favor of preserving physical attributes and additional constraints.

 

 

Last Updated Date : 30/12/2012