Structural and Computational Biology

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  1. The T-cell Repertoire
  2. Single-cell RNA sequencing
  3. Networks in Cancer Genomics
  4. Predicting drug response through cancer genomics

Prof. Efroni Sol

  1.  Investigation of the mechanism of the protein folding transition (towards solution of the "second genetic code").
  2. Investigation of the dynamics of nano-molecular structures by means of time resolved FRET measurements.
  3. Study of the initial structural events in the Synuclein molecules, which lead to the onset of Parkinson disease and means for prevention.

Prof. Haas Elisha

  1. How the genome is folded in 3D in plant cells and how this folding is linked to gene regulation
  2. Identifying novel regulatory elements and gene regulatory networks in the plant genome
  3. Mechanisms of positive and negative transcriptional response to a single transcription factor.
  4. Rapid transcriptional response of immune cell to steroid hormones
  5. How the genome is organized in 3D during cellular differentiation and cancer progression.
  6. Identifying transcription factors driving tumorigenic transformation in breast cancer.

Dr. Hakim Ofir

  1. How do animal social networks form?
  2. What are rock hyraxes are talking about? The evolution of vocal communication
  3. Computational models of social networks
  4. Using drones for observation and experiments

Dr. Ilany Amiyaal

  1. Computational genomics
  2. RNA editing by ADAR proteins
  3. DNA editing by APOBEC proteins
  4. Transcriptome complexity
  5. Mobile elements in the genome
  6.  RNA editing in diseases

Prof. Levanon Erez

  1. Models and simulations of the dynamics of the development of T and B lymphocytes, the rearrangement of B cell and T cell antigen receptor genes, and subsequent selection, which is based on receptor-ligand interactions.
  2. Models for the development of the natural killer (NK) cell repertoire, from receptor gene expression to selection of functional, non-harmful cells.
  3. Studies of the competition between B lymphocyte clones during the humoral immune response, the process of hypermutation, and the creation of memory cells, including the explanation of the phenomenon of repertoire shift, isotype switch, and graph-theoretical analysis of B lymphocyte immunoglobulin gene phylogenetic trees.

Prof. Mehr Ramit

  1. Bio-molecular recognition - Studying the mechanisms that allow proteins to recognize and bind other bio-molecules
  2. Analysis, design and engineering of antibodies
  3. Studying diseases and developing drugs using tools from data science
  4. Predicting phenotype from genome
  5. Protein function prediction

Prof. Ofran Yanay

  1. Structural biology - X-ray crystallography
  2. Drug design
  3. Axon guidance - the Slit-Robo signaling system
  4. Molecular basis for human brain evolution

Prof. Opatowsky Yarden

  1. Understanding protein folding
  2. Computational analysis of ncRNA in Trypanosomes
  3. Studying the genetic components of Human diseases
  4. Using Machine learning for medical data mining

Prof. Unger Ron