Immunology and Cancer Research

עברית
ResearcherResearch Focus
Prof. Barda-Saad Mira
  1. Investigating the molecular mechanisms regulating the immune response by using advanced molecular imaging technologies.
  2. Developing novel immunotherapeutic approaches to treat cancer.
  3. Studying primary immunodeficiencies and developing therapeutic strategies.
  4. Boosting natural killer cell immune response in pathologies.
Prof. Ben-Aroya Shay 
  1. Understanding how eukaryotic cells keep their genome stable
  2. How eukaryotic cells distinguish properly folded from misfolded proteins, to prevent proteotoxic stress, and neurodegenerative diseases.
  3. Molecular genetics and cell biology of the model system, the yeast Saccharomyces cerevisiae.
Prof. Cohen Cyrille
  1. Development of novel immunotherapies for cancer and viral diseases.
  2. Genetic engineering and editing of immune cells to express chimeric receptors (CAR-T and CCR-T cells).
  3. Utilization of the tumor environment to enhance anti-tumor immunity.
  4. Study of immune exhaustion mechanisms and their inhibition to improve immunity.
  5. Development of theranostic approaches and use of antibody-targeted nanoparticles (in collaboration with Prof. Popovtzer - Faculty of Engineering).
  6. Characterization of the anti-tumor immune response and identification of novel immune targets.
  7. Enhancement of T-cell motility to tumors and metastasis.
Prof. Cohen Haim
  1. The molecular base of aging, the role of deacetylases in life longevity.
  2. The molecular pathways that regulate the response for caloric restriction.
  3. The molecular and cellular biology of sirtuin deacetylases.
  4. Isolating new proteins that regulate longevity in mammals.
Prof. Efroni Sol
  1. The T-cell Repertoire
  2. Single-cell RNA sequencing
  3. Networks in Cancer Genomics
  4. Predicting drug response through cancer genomics
Prof. Ginsberg Doron
  1. Elucidation of the molecular mechanism that mediates the effects of E2F on cell fate and intracellular signaling.
  2. Studying the mechanisms by which E2F1 sensitizes cells to chemotherapeutic treatments.
  3. Studying the crosstalk between E2Fs and signal transduction pathways.
  4. Isolation and characterization of novel E2F-regulated genes that affect autophagy. Elucidating the role of E2Fs in the regulation of autophagy.
  5. Identification of novel molecular links between E2F1 and the tumor suppressor p53.
Dr. Knisbacher Binyamin
  1. RNA aberrations that drive cancer
  2. Neoantigens derived from RNA aberrations for immunotherapy applications
  3. Integrating sequencing and drug screen data for personalized medicine
  4. Identifying cancer cell vulnerabilities
  5. Cancer and immune heterogeneity via single-cell RNA-seq analysis
Prof. Okun Eitan

  1. The functional role of the immune system in Alzheimer's disease

  2. How fetal development influences maternal cognitive decline
  3. Developing vaccines for Alzheimer’s disease and Down syndrome
Prof. Opatowsky Yarden
  1. Structural biology - X-ray crystallography
  2. Drug design
  3. Axon guidance - the Slit-Robo signaling system
  4. Molecular basis for human brain evolution
Dr. Roichman Asael
  1. Metabolite discovery using state-of-the-art HPLC and high-resolution LC-MS platforms coupled with advanced computational pipelines
  2. Identifying bioactive metabolites formed at the diet–gut microbiota–host interface, with a focus on metabolites found in plant-based foods (phytochemicals)
  3. Understanding how diet and the microbiome shape liver function
  4. Revealing mechanisms by which diet–microbiome interactions modulate cancer development and therapeutic response
Prof. Shav-Tal Yaron
  1. Following mRNAs in living cells using high-resolution fluorescence microscopy
  2. Examining gene expression and transcription of single alleles in living cells in real-time
  3. Studying RNA processing factors in time and nuclear space
  4. Following long non-coding RNAs in the nucleus under normal and stress conditions
  5. Tracking the exit of mRNAs from the nucleus and through the nuclear pore using super-resolution microscopy and live-cell imaging
  6. Following signal transduction pathways that induce the activation of genes expressed in normal and cancer cells
  7. Examining stress-induced cytoplasmic granules and understanding their function in cells
Dr. Yissachar Nissan
  1. Mechanisms of host-microbiome communications
  2. Intestinal neuro-immune-microbiome interactions
  3. Effects of the gut microbiota on autoimmunity and cancer
  4. Computational biology / bioinformatics – analysis of host and microbiome transcriptomics
Prof. Emeritus Brodie Chaya
  1. Cancer stem cells from brain tumors for analyzing disease mechanisms and for drug and cell therapy screening
  2. Three dimensional human cultures - novel models of neural rare disorders and muscular dystrophies
  3. Exosomes in intercellular communication and drug delivery in neural and muscle diseases and brain tumors.
  4. Non-coding RNAs in cancer and degenerative disorders
  5. Unique signaling pathways in brain tumors and neurodegenerative diseases
Prof. Emeritus Nir Uri
  1. Studying the reprogrammed metabolic and enrgy generation systems of cancer cells.
  2. Studying the regulatory role of the FerT kinase, which is solely present in the mitochondria of sperm and cancer cells.
  3. Development of new anti-cancer drugs, which selectively target the reprorammed mitochondria of cancer cells in general, and metastatic malignant cells in particular.
Prof.  Emeritus Shredni Benjamin
  1.  Prevention of Chemotherapy-Induced Hematopoietic Damage by Oral Administration of SAS : Potential Role of VLA-4 Inactivation by the Compound
  2. Effect of the Tellurium compound SAS on PD-L1 Expression in AML: Mechanism of Action and Clinical Aspects
  3. Effect of the Tellurium Compound SAS on the Reciprocal leukemia- Stroma VLA-4-Dependent Activation of NF-kB Mediated Chemoresistance
  4. Effect of Tellurium Compound AS101 on PD-L1 Expression on Human NSCLC : Mechanism of Action and Correlation with Clinical Results in NSCLC Patients
  5. Effect of the Tellurium Compound SAS on PD-L1 Expression on Human and Murine Melanoma: Mechanism of Action and Clinical Aspects