ד"ר מוטרו בני

ד"ר
מרצה בכיר
ד"ר בני מוטרו
דוא"ל: 
טלפון: 
מיקום: 

קורות חיים

Education

 

1978-1980, BSc, with honors, in Agriculture

Dept. of Microbiology, Faculty of Agriculture

Hebrew University of Jerusalem, Rehovot

 

1981-1982, MSc, with honors

Dept. of Microbiology, Faculty of Agriculture

Hebrew University of Jerusalem, Rehovot

 

1985-1989, PhD

Dept. of Virology, Faculty of Medicine

Hebrew University, Jerusalem

 

1990-1993, POSTDOCTORAL RESEARCH FELLOW

Molecular and Developmental Biology

Dr. Alan Bernstein's laboratory, Mount Sinai Hospital Research Institute

Toronto, Canada

 

1991-1993, FELLOW

Leukemia Research Fund, Canada

 

1993-1996, FELLOW

Yigal Alon Fellowship

 

 

Positions

 

2002-present, SENIOR LECTURER

Cellular and Developmental Biology

The Mina & Everard Goodman Faculty of Life Sciences

Bar-Ilan University, Ramat-Gan, Israel

 

Oct 2001-Feb 2002, SABBATICAL, Developmental Biology

Dr. Alan Bernstein’s laboratory, Mount Sinai Hospital Research Institute

Toronto, Canada

 

1993-2002, LECTURER

Cellular and Developmental Biology

Faculty of Life Sciences, Bar-Ilan University

Ramat-Gan, Israel

 

1983-1984, RESEARCH ASSOCIATE

Composting of organic wastes for CO2 production

Migal Laboratories, Kiryat Shmona

 

 

Organization of conference

 

1997, Gene Targeting in vivo – the Impact of Gene Targeting

Ayelet Hashachar, Israel

 

 

Participation in Meetings of the EU consortium on

“Development of an Implanted Biosensor for Continuous

Care and Monitoring System of Diabetic Patients”:

Kick-off Meeting, Munich, Germany, Sept 12-13 2006

Six Months Meeting, Tel-Aviv, Feb 27-28, 2007

1st Year Review Meeting, Como, Italy,  July 16-18, 2007

Executive Board Meeting, Munich, Germany, Dec 13-14, 2007

18 Months Meeting, Prague, Feb 27 – March 1, 2008

תקשורת

 
972-3-531-8149
972-3-738-4058
motro@mail.biu.ac.il

Office Location:

Life Sciences Building (212), 3rd floor, Room 301

Contact Address:

The Mina & Everard Goodman Faculty of Life Sciences 
Bar-Ilan University 
Ramat-Gan 52900 
Israel

פרסומים

He, Y., Zeng, M.Y., Yang, D., Motro, B., and Núñez, G. (2016). NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux. Nature 530, 354–357.

Cohen S, Aizer A, Shav-Tal Y, Yanai A, Motro B. (2013). Nek7 kinase accelerates microtubule dynamic instability. BBA Mol. Cell Res. 1833:1104-13.

Lachke, S.A., Higgins, A.W., Inagaki, M., Saadi, I., Xi, Q., Long, M., Quade, B.J., Talkowski, M.E., Gusella, J.F., Fujimoto, A., et al. (2012). The cell adhesion gene PVRL3 is associated with congenital ocular defects. Hum. Genet. 131, 235–250.

Lerer-Goldshtein, T., Bel, S., Shpungin, S., Pery, E., Motro, B., Goldstein, R.S., Bar-Sheshet, S.I., Breitbart, H., and Nir, U. (2010). TMF/ARA160: A key regulator of sperm development. Dev. Biol. 348, 12–21.

Noy-Lotan, S., Dgany, O., Lahmi, R., Marcoux, N., Krasnov, T., Yissachar, N., Ginsberg, D., Motro, B., Resnitzky, P., Yaniv, I., et al. (2009). Codanin-1, the protein encoded by the gene mutated in congenital dyserythropoietic anemia type I (CDAN1), is cell cycle-regulated. Haematologica 94, 629–637.

Levitan, D., Lyons, L.C., Perelman, A., Green, C.L., Motro, B., Eskin, A., and Susswein, A.J. (2008). Training with inedible food in Aplysia causes expression of C/EBP in the buccal but not cerebral ganglion. Learn. Mem. 15, 412–416.

Feige, E., Shalom, O., Tsuriel, S., Yissachar, N., and Motro, B. (2006). Nek1 shares structural and functional similarities with NIMA kinase. Biochim. Biophys. Acta 1763, 272–281.

Yissachar, N., Salem, H., Tennenbaum, T., and Motro, B. (2006). Nek7 kinase is enriched at the centrosome, and is required for proper spindle assembly and mitotic progression. FEBS Lett. 580, 6489–6495.

Sredni, B., Gal, R., Cohen, I.J., Dazard, J.-E., Givol, D., Gafter, U., Motro, B., Eliyahu, S., Albeck, M., Lander, H.M., et al. (2004). Hair growth induction by the Tellurium immunomodulator AS101: association with delayed terminal differentiation of follicular keratinocytes and ras-dependent up-regulation of KGF expression. FASEB J. 18, 400–402.

Feige, E., and Motro, B. (2002). The related murine kinases, Nek6 and Nek7, display distinct patterns of expression. Mech. Dev. 110, 219–223.

Fliess, A., Motro, B., and Unger, R. (2002). Swaps in protein sequences. Proteins 48, 377–387.

Ben-Zur, T., Feige, E., Motro, B., and Wides, R. (2000). The mammalian Odz gene family: homologs of a Drosophila pair-rule gene with expression implying distinct yet overlapping developmental roles. Dev. Biol. 217, 107–120.

Kandli, M., Feige, E., Chen, A., Kilfin, G., and Motro, B. (2000). Isolation and characterization of two evolutionarily conserved murine kinases (Nek6 and nek7) related to the fungal mitotic regulator, NIMA. Genomics 68, 187–196.

Lourenssen, S., Motro, B., Bernstein, A., and Diamond, J. (2000). Defects in sensory nerve numbers and growth in mutant Kit and Steel mice. Neuroreport 11, 1159–1165.

Chen, A., Yanai, A., Arama, E., Kilfin, G., and Motro, B. (1999). NIMA-related kinases: isolation and characterization of murine nek3 and nek4 cDNAs, and chromosomal localization of nek1, nek2 and nek3. Gene 234, 127–137.

Mesilaty-Gross, S., Reich, A., Motro, B., and Wides, R. (1999). The Drosophila STAM gene homolog is in a tight gene cluster, and its expression correlates to that of the adjacent gene ial. Gene 231, 173–186.

Reich, A., Yanai, A., Mesilaty-Gross, S., Chen-Moses, A., Wides, R., and Motro, B. (1999). Cloning, mapping, and expression of ial, a novel Drosophila member of the Ipl1/aurora mitotic control kinase family. DNA Cell Biol. 18, 593–603.

Arama, E., Yanai, A., Kilfin, G., Bernstein, A., and Motro, B. (1998). Murine NIMA-related kinases are expressed in patterns suggesting distinct functions in gametogenesis and a role in the nervous system. Oncogene 16, 1813–1823.

Schwartz, Y., Ben-Dor, I., Navon, A., Motro, B., and Nir, U. (1998). Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases. FEBS Lett. 434, 339–345.

Klüppel, M., Donoviel, D.B., Brunkow, M.E., Motro, B., and Bernstein, A. (1997). Embryonic and adult expression patterns of the Tec tyrosine kinase gene suggest a role in megakaryocytopoiesis, blood vessel development, and melanogenesis. Cell Growth Differ. 8, 1249–1256.

Yanai, A., Arama, E., Kilfin, G., and Motro, B. (1997). ayk1, a novel mammalian gene related to Drosophila aurora centrosome separation kinase, is specifically expressed during meiosis. Oncogene 14, 2943–2950.

Mélet, F., Motro, B., Rossi, D.J., Zhang, L., and Bernstein, A. (1996). Generation of a novel Fli-1 protein by gene targeting leads to a defect in thymus development and a delay in Friend virus-induced erythroleukemia. Mol. Cell. Biol. 16, 2708–2718.

Motro, B., Wojtowicz, J.M., Bernstein, A., and van der Kooy, D. (1996). Steel mutant mice are deficient in hippocampal learning but not long-term potentiation. Proc. Natl. Acad. Sci. U. S. A. 93, 1808–1813.

Fode, C., Motro, B., Yousefi, S., Heffernan, M., and Dennis, J.W. (1994). Sak, a murine protein-serine/threonine kinase that is related to the Drosophila polo kinase and involved in cell proliferation. Proc. Natl. Acad. Sci. U. S. A. 91, 6388–6392.

Motro, B., and Bernstein, A. (1993). Dynamic changes in ovarian c-kit and Steel expression during the estrous reproductive cycle. Dev. Dyn. 197, 69–79.

Letwin, K., Mizzen, L., Motro, B., Ben-David, Y., Bernstein, A., and Pawson, T. (1992). A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells. EMBO J. 11, 3521–3531.

Motro, B., van der Kooy, D., Rossant, J., Reith, A., and Bernstein, A. (1991). Contiguous patterns of c-kit and steel expression: analysis of mutations at the W and Sl loci. Development 113, 1207–1221.

Motro, B., Itin, A., Sachs, L., and Keshet, E. (1990). Pattern of interleukin 6 gene expression in vivo suggests a role for this cytokine in angiogenesis. Proc. Natl. Acad. Sci. U. S. A. 87, 3092–3096.

מחקר


Research Fields

MOLECULAR EMBRYOLOGY

 

A. The cellular and developmental roles of the mammalian Nek kinases:

The NIMA-related (Nek) family of protein kinase is emerging as evolutionarily conserved and key cell cycle regulatory proteins. Mammalian genomes harbor 11 members of this family, several of which were first cloned and characterized in our laboratory. The functions of these enzymes are still quite mysterious and the major aims of our lab are:

  1. To decipher the cellular and developmental roles of the Nek kinases mainly by employing classical and inducible gene targeting approaches.
  2. To identify the signaling modules in which Nek7 participate. A methodology designated Stable Isotopic Labeling with Amino Acids in Cell Culture (SILAC) enables us to identify proteins differentially expressed or modified in wt versus Nek7 mutant MEF cells. The lists of Nek7-affected proteins suggest novel functions in cytoskeleton arrangement and cell adhesion, roles which are currently substantiated and investigated.  

B. The molecular functions of Codanin-1

The congenital dyserythropoietic anemias (CDAs) are a group of rare inherited disorders characterized by impaired erythropoiesis and characteristic cytopathology of erythroid cells. In collaboration with Prof. Hannah Tamary from Schneider Children's Medical Center, we are studying the major etiological agent of CDA-1, the codanin-1 protein. Mutant mice and cells serve to identify erythropoietic-specific function as well as ubiquitous molecular functions.