Neurobiology

Neurobiology is a field of research devoted to research of the nervous system. This field of research bridges between diverse fields of research, beginning with biochemistry, molecular biology, physiology and genetics, through computer sciences and ending with psychology and philosophy. It can be said that the main goal of neurobiology is to explain behavior in terms of neural activity. How does the brain recruit billions upon billions of nerve cells in order to create behavior? How are nerve cells in the brain affected by behavior? The last and perhaps greatest challenge of the biological sciences is neurobiological research which tries to explain the basis for consciousness and the basic processes by which we sense, act, learn and remember. At the molecular level, the basic questions that are investigated include mechanisms of expression and use of cellular information carriers which in turn contribute to cellular activities such as gene expression and cell death. The strong connection between the shape of the various nerve cells and their physiological properties has also been extensively researched in recent years. At the cellular level, researchers use electrophysiological methods and advanced microscopes for investigating how a single cell processes the electric signals which enter it through the dendritic tree and leave it via the axon and its branches. At the cognitive level, questions are studied which connect between conditions of nerve cell network activity and behavior.

Prof. Appelbaum Lior

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    Prof. Brodie Chaya

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      Prof. Korngreen Alon

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        Dr. Okun Eitan

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          Dr. Opatowsky Yarden

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            Dr. Shohat-Ophir Galit

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            media

            Publications

            1. G. Shohat-Ophir, K R. Kaun, R. Azanchi, H. Mohammed, and U. Heberlein Sexual deprivation increases ethanol intake in Drosophila. (2012) Science. 335:1351-5. (Recommended by Faculty of 1000 as a must to read).


            2. Guenebeaud C, Goldschneider D, Castets M, Guix C, Chazot G, Delloye-Bourgeois C, Eisenberg-Lerner A, Shohat G, Zhang M, Laudet V, Kimchi A, Bernet A, Mehlen P. (2010) The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase. Mol Cell. 40: 863-876.


            3. Corl AB, Berger KH, Ophir-Shohat G, Gesch J, Simms JA, Bartlett SE, Heberlein U. (2009) Happyhour, a Ste20 family kinase, implicates EGFR signaling in ethanol-induced behaviors. Cell. 137(5):949-60.


            4. Gozuacik D, Bialik S, Raveh T, Mitou G, Shohat G, Sabanay H, Mizushima N, Yoshimori T, and Kimchi A. (2008) DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagoc cell death. Cell Deah Differ. 15:1875-86.


            5. Citri A, Harari D, Shohat G, Ramakirsham P, Gan J, Eisenstein M, Kimchi A, Wallach D, Pietrokovski A and Yarden A. (2006) Hsp90 recognizes a common surface on client kinases. J Biol Chem. 19;281(20):14361-9.


            6. Shani G, Marash L, Gozuacik D, Bialik S, Teitelbaum L, Shohat G, Kimchi A. (2004) Death-associated protein kinase phosphorylates ZIP kinase, forming a unique kinase hierarchy to activate its cell death functions. Mol. Cell Biol. 24:8611-26.


            7. Toledano-Katchalski H, Kraut J, Sines T, Granot-Attas S, Shohat G, Gil-Henn H, Yung Y, Elson A. (2003) Protein tyrosine phosphatase epsilon inhibits signaling by mitogen-activated protein kinases. Mol. Cancer Res. 7:541-50.


            8. Shohat G, Spivak-Kroizman T, Eisenstein M, Kimchi A. (2002) The regulation of death-associated protein (DAP) kinase in apoptosis. Eur. Cytokine Netw. 13:398-400.


            9. Shohat G, Shani G, Eisenstein M, Kimchi A. (2002) The DAP-kinase family of proteins: study of a novel group of calcium-regulated death-promoting kinases. Biochim. Biophys. Acta.1600:45-50.


            10. Henis-Korenblit S, Shani G, Sines T, Marash L, Shohat G, Kimchi A. (2002) The caspase-cleaved DAP5 protein supports internal ribosome entry site-mediated translation of death proteins. Proc. Natl. Acad. Sci. USA. 99:5400- 5.

            11. Shohat G, Spivak-Kroizman T, Cohen O, Bialik S, Shani G, Berrisi H, Eisenstein M, Kimchi A. (2001) The pro- apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation- based mechanism. J. Biol. Chem. 276:47460-7.


            12. Seluanov A, Gorbunova V, Falcovitz A, Sigal A, Milyavsky M, Zurer I, Shohat G, Goldfinger N, Rotter V. (2001) Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53. Mol. Cell Biol. 21:1552-64.

            Prof. Susswein Abraham

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              Prof. Yadid Gal

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