Neurobiology

Neurobiology is a field of research devoted to research of the nervous system. This field of research bridges between diverse fields of research, beginning with biochemistry, molecular biology, physiology and genetics, through computer sciences and ending with psychology and philosophy. It can be said that the main goal of neurobiology is to explain behavior in terms of neural activity. How does the brain recruit billions upon billions of nerve cells in order to create behavior? How are nerve cells in the brain affected by behavior? The last and perhaps greatest challenge of the biological sciences is neurobiological research which tries to explain the basis for consciousness and the basic processes by which we sense, act, learn and remember. At the molecular level, the basic questions that are investigated include mechanisms of expression and use of cellular information carriers which in turn contribute to cellular activities such as gene expression and cell death. The strong connection between the shape of the various nerve cells and their physiological properties has also been extensively researched in recent years. At the cellular level, researchers use electrophysiological methods and advanced microscopes for investigating how a single cell processes the electric signals which enter it through the dendritic tree and leave it via the axon and its branches. At the cognitive level, questions are studied which connect between conditions of nerve cell network activity and behavior.

Prof. Appelbaum Lior

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Publications

  1. Eban-Rothschild A, Appelbaum L, de Lecea L (2017) Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive. Neuropsychopharmacology. In press.

  2. Levitas-Djerbi T, Appelbaum L (2017). Modeling sleep and neuropsychiatric disorders in zebrafish. Curr Opin Neurobiol. 44:89-93 doi: 10.1016/j.conb.2017.02.017. 

  3. Zada D, Blitz E, Appelbaum L (2017). Zebrafish - An emerging model to explore thyroid hormone transporters and psychomotor retardation. Mol Cell Endocrinol. pii: S0303-7207(17)30172-7. doi: 10.1016/j.mce.2017.03.004. 

  4. Elbaz I, Levitas-Djerbi T, Appelbaum L (2016). The Hypocretin/Orexin Neuronal Networks in Zebrafish. Curr Topics Behav Neuroscience. 2017;33:75-92 doi: 10.1007/7854_2016_59. 

  5. Elbaz I, Zada D, Tovin A, Braun T, Lerer-Goldshtein T, Wang G,  Mourrain P, Appelbaum L (2016). Sleep-Dependent Structural Synaptic Plasticity of Inhibitory Synapses in the Dendrites of Hypocretin/Orexin Neurons. Molecular Neurobiology. 

  6. Zada D, Tovin A, Lerer-Goldshtein T, Appelbaum L  (2016). Pharmacological and BBB-targeted genetic therapies for thyroid hormone-dependent hypomyelination. Disease Models & Mechanisms.  pii: dmm.027227. 

  7. Shamay-Ramot A, Khermesh K, Porath HT, Barak M, Pinto Y, Wachtel C, Zilberberg A, Lerer-Goldshtein T, Efroni S, Levanon EY, and Appelbaum L (2015). Fmrp interacts with Adar and regulates RNA editing, synaptic density and locomotor activity in zebrafish. PLoS Genet. 11:e1005702.

  8. Yelin-Bekerman L, Elbaz I, Diber A, Dahary D, Gibbs-Bar L, Alon S, Lerer-Goldshtein T, Appelbaum L. (2015). Hypocretin neuron-specific transcriptome profiling identifies the sleep modulator Kcnh4a. eLife. 4. pii: e08638. 

  9. Oren M, Tarrant AM, Alon S, Simon-Blecher N, Elbaz I, Appelbaum L and Levy O. (2015). Profiling molecular and behavioral circadian rhythms in the non-symbiotic sea anemone Nematostella vectensis. Scientific reports. 5:11418. 

  10. Levitas-Djerbi T, Yelin-Bekerman L, Lerer-Goldshtein T, Appelbaum L.(2015). The Hypothalamic Leptin-Neurotensin-Hypocretin Neuronal Networks in Zebrafish. J Comp Neurol. 523:831-848. 

  11. Elbaz I, Lerer-Goldshtein T, Okamoto H, Appelbaum L. (2015).  Reduced synaptic density and deficient locomotor response in neuronal activity-regulated pentraxin 2a mutant zebrafish. FASEB J.  29:1220-34. 

  12. Zada D, Tovin A, Lerer-Goldshtein T, Vatine GD, Appelbaum L. (2014). Altered behavioral performance and live imaging of circuit-specific neural deficiencies in a zebrafish model for psychomotor retardation. PLoS Genet 10:e1004615. 

  13. Sharaby Y, Lahmi R, Amar O, Elbaz I, Lerer-Goldshtein T, Weiss AM, Appelbaum L, Tzur A. (2014). Gas2l3 is essential for brain morphogenesis and development. Dev Biol. 394:305-13. 

  14. Oren M, Brikner I, Appelbaum L, Levy O. (2014). Fast neurotransmission related genes are expressed in non nervous endoderm in the sea anemone Nematostella vectensis. PLoS One. 9:e93832.  

  15. Elbaz, I., Foulkes, N.S., Gothilf, Y., and Appelbaum, L. (2013). Circadian clocks, rhythmic synaptic plasticity and the sleep-wake cycle in zebrafish. Frontiers in Neural Circuits 7:9.​ 

  16. Vatine, G.D., Zada, D., Lerer-Goldshtein, T., Tovin, A., Malkinson, G., Yaniv, K., and Appelbaum, L. (2013). Zebrafish as a model for monocarboxyl transporter 8-deficiency. J Biol Chem 288, 169-180.​ 

  17. Elbaz I, Yelin-Bekerman L, Nicenboim J, Vatine G, and Appelbaum L (2012) Genetic ablation of hypocretin neurons alters behavioral state transitions in zebrafish. The Journal of Neuroscience 32:12961–12972.​ 

  18. Wang G, Grone B, Colas D, Appelbaum L and Mourrain P (2011) Synaptic plasticity in sleep: learning, homeostasis and disease. Trends in Neurosciences. 34:452-63.​ 

  19. Appelbaum L, Wang G, Yokogawa T, Skariah G, Smith SJ, Mourrain P and Mignot E (2010) Circadian and homeostatic regulation of structural synaptic plasticity in hypocretin neurons. Neuron. 68:87-98 (cover)*.​ *This paper was highlighted in Nature: Neuroscience: Brain connections have rhythm. Nature 468: 349.​

  20. Appelbaum L, Wang G, Maro G, Mori R, Tovin A, Marin W, Yokogawa Y, Kawakami K, Smith SJ, Gothilf Y, Mignot EM and Mourrain P (2009). Sleep/wake regulation and hypocretin-melatonin interaction in zebrafish. Proceedings of the National Academy of Sciences U S A. 106:21942-21947 (track II). ​

  21. Vatine G, Vallone D, Appelbaum L, Mracek P, Ben-Moshe Z, Lahiri K, Gothilf Y and Foulkes NS (2009) Light directs zebrafish period2 expression via conserved D and E boxes. PLoS Biology. 7:e1000223. 

  22. Levy O, Appelbaum L, Leggat W, Gothlif Y, Hayward DC, Miller DJ and Hoegh-Guldberg O (2007) Light-responsive cryptochromes from the simplest marine eumetazoan animals. Science. 318: 467-470.​

  23. Yokogawa T, Marin W, Faraco J, Pezeron G, Appelbaum L, Zhang J, Rosa F, Mourrain P and Mignot E (2007) Characterization of sleep in zebrafish and insomnia in hypocretin receptor mutants. PLoS Biology. 5: 2379-2397.​

  24. Appelbaum L, Skariah G, Mourrain P and Mignot E (2007) Purinergic transmission by P2X receptors and ecto-nucleoside triphosphate diphosphohydrolase 3 in hypocretin and sensory neurons in zebrafish. Brain Research. 1174: 66-75.​

  25. Zilberman-Peled* B, Appelbaum* L, Vallone D, Foulkes NS, Anava S, Anzulovich A, Coon SL, Klein DC, Falcon J,  Ron B and Gothilf Y (2007) Transcriptional regulation of arylalkylamine-N-acetyltransferase-2 gene in the pineal gland of the gilthead seabream. Journal of Neuroendocrinology. 19:46-53. *Equally contributed.​

  26. Faraco* JH, Appelbaum* L, Marin W, Gaus S, Mourrain P, Mignot E (2006) Regulation of hypocretin (orexin) expression in embryonic zebrafish. Journal of Biological Chemistry. 281: 29753-61. *Equally contributed. 

  27. 18 Appelbaum L, Gothilf Y (2006) Mechanism of pineal-specific gene expression: The role of E-box and photoreceptor conserved elements. Molecular and Cellular Endocrinology. 252: 27-33. ​

  28. Appelbaum L, Vallone D, Anzulovich A, Ziv L, Tom M, Foulkes N, Gothilf Y (2006) Zebrafish arylalkylamine-N-acetyltransferase genes - targets for regulation of circadian-clock. Journal of Molecular Endocrinology. 36: 337-347. 

  29. Appelbaum L, Anzulovich A, Baler R, Gothilf Y (2005) Homeobox-clock protein interaction in zebrafish: A shared mechanism for pineal-specific and circadian gene expression. Journal of Biological Chemistry 280: 11544–11551.​

  30. Appelbaum L, Toyama R, Dawid IB, Klein DC, Baler R, Gothilf Y (2004) Zebrafish serotonin-N-acetyltransferase-2 gene regulation: Pineal-restrictive downstream module (PRDM) contains a functional E-box and three photoreceptor conserved elements. Molecular Endocrinology 18: 1210-1221.​

  31. Appelbaum L, Achituv Y, Mokady O (2002) Speciation and the establishment of zonation in an intertidal barnacle - specific settlement versus selection. Molecular Ecology 11: 1731-1737.

Prof. Brodie Chaya

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    Prof. Korngreen Alon

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      Dr. Okun Eitan

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      Publications

       

      1. A protocol for quantitative analysis of murine and human amyloid-β1-40 and 1-42. Illouz T, Madar R, Griffioen K, Okun E. J Neurosci Methods. 2017 Nov 1;291:28-35. doi: 10.1016/j.jneumeth.2017.07.022. Epub 2017 Jul 30.
      2. Lavian H, Almog M, Madar R, Loewenstern Y, Bar-Gad I, Okun E, Korngreen A. Dopaminergic modulation of synaptic integration and firing patterns in the rat entopenduncular nucleus. J Neurosci. 2017 Jun 26. pii: 0639-17.
      3. Okun E, Marton D, Cohen D, Griffioen K, Kanfi Y, Illouz T, Madar R, Cohen HY. Sirt6 alters adult hippocampal neurogenesis. PLoS One. 2017 Jun 23;12(6):e0179681
      4. Betzer O, Shilo M, Opochinsky R, Barnoy E, Motiei M, Okun E, Yadid G, Popovtzer R. The effect of nanoparticle size on the ability to cross the blood-brain barrier: an in vivo study. Nanomedicine (Lond). 2017 Jul;12(13):1533-1546
      5. Gross A, Benninger F ,Madar R, Illouz T, Griffioen K, Steiner I, Offen D and Okun E. Toll-like receptor 3 deficiency decreases epileptogenesis in pilocarpine model of SE-induced epilepsy in mice. Epilepsia. 2017 Feb 6.
      6. Illouz T, Madar R, Clague C, Griffioen K, Louzoun Y, Okun E. Unbiased classification of spatial strategies in the Barnes maze. Bioinformatics. 2016 Jul 4. [IF# 5.766, ranked 3 of 65 journals in Mathematical and computational Biology, A+].
      7. Illouz T, Madar R, Louzon Y, Griffioen KJ, Okun E. Unraveling cognitive traits using the Morris water maze unbiased strategy classification (MUST-C) algorithm. Brain, Behavior and Immunity. 2015 Oct 24. [IF# 5.874; ranked 24 of 151 journals in Immunology, A].
      8. Madar R, Rotter A, Ben-Asher HW, Mughal MR, Arumugam TV, Wood WH 3rd, Becker KG, Mattson MP and Okun E. Postnatal TLR2 activation impairs learning and memory in adulthood. Brain, Behavior and Immunity, 2015 Aug;48:301-12. [IF# 5.874; ranked 24 of 151 journals in Immunology, A].
      9. Feldman N, Rotter A, Okun E. DAMPs as mediators of sterile inflammation in aging-related pathologies. Ageing Res Rev. 2015 Jan 29. pii: S1568-1637(15)00005-7. [IF# 7.526; ranked 1 of 49 journals in Geriatrics and Gerontology, A+].
      10. Illouz T, Okun E. No ECSIT-stential evidence for a link with Alzheimer's disease yet (retrospective on DOI 10.1002/bies.201100193). Bioessays. 2014 Nov 4. [IF# 4.73; ranked 10 of 86 journals in Biology, A].

      11. Barak B, Feldman N, Okun E. Cardiovascular Fitness and Cognitive Spatial Learning in Rodents and in Humans. J Gerontol A Biol Sci Med Sci. 2014 Sep 16. [IF# 5.416; ranked 3 of 50 journals in Geriatrics and Gerontology, A+].
      12. Barak B, Feldman N, Okun E. Toll-like receptors as developmental tools that regulate neurogenesis during development: an update. Front Neurosci. 2014 Aug 28;8:272. [IF# 3.656; ranked 82 of 252 journals in Neurosciences, C].
      13. Kim W, Fiori JL, Shin YK, Okun E, Kim JS, Rapp PR, Egan JM. Pancreatic polypeptide inhibits somatostatin secretion. FEBS Lett. 2014 Aug 25;588(17):3233-9. doi: 10.1016/j.febslet.2014.07.005. [IF# 3.17; ranked 20 of 72 journals in Biophysics, B].
      14. Okun E. A heavy toll on the outcome of ischemic brain stroke. Exp Neurol. 2014 Apr;254:166-7. doi: 
10.1016/j.expneurol.2014.02.002. Epub 2014 Feb 7. [IF# 4.67; ranked 47 of 252 journals in Neurosciences, A].
      15. Lee JH, Halperin-Sheinfeld M, Baatar D, Mughal MR, Tae HJ, Kim JW, Carter A, Lustig A, Snir O, 
Lavie G, Okun E, Mattson MP, Sredni B, Taub DD. Tellurium Compound AS101 Ameliorates Experimental Autoimmune Encephalomyelitis by VLA-4 Inhibition and Suppression of Monocyte and T Cell Infiltration into the CNS. Neuromolecular Med. 2013 Nov 23. [IF# 3.885; ranked 77 of 252 journals in Neurosciences, C].
      16.  Okun E, Griffioen KJ, Rothman S, Wan R, Cong W, De Cabo R, Montalvo AM, Levette A, Maudsley S, Martin B, Arumugam TV and Mattson MP. Toll-Like Receptors 2 and 4 Modulate Autonomic Control of Heart Rate and Energy Metabolism. Brain Behav Immun. 2013 Oct 18. pii: S0889-1591(13)00512-6. doi: 10.1016/j.bbi.2013.10.013. [IF# 6.128; ranked 19 of 144 journals in Immunology, A].
      17. Cheng Y, Park JS, Manzanero S, Choi Y, Baik S, Okun E, Gelderblom M, Fann DY, Magnus T, Launikonis B, Mattson MP, Sobey C, Jo DG and Arumugam TV. Evidence that Collaboration between HIF-1alpha and Notch-1 Promotes Neuronal Cell Death in Ischemic Stroke. Neurobiology of Disease. 2014 Feb;62:286-95. [IF# 5.078; ranked 39 of 252 journals in Neurosciences, A].
      18. Barak B, Shvarts-Serebro I, Modai S, Gilam A, Okun E, Michaelson DM, Mattson MP, Shomron N, Ashery U. Opposing actions of environmental enrichment and Alzheimer's disease on the expression of hippocampal microRNAs in mouse models. Transl Psychiatry. 2013 Sep 10;3:e304. [IF# 4.3; ranked 24 of 136 journals in Psychiatry, A].
      19. Barak B, Okun E, Ben-Simon Y, Lavi A, Shapira R, Madar R, Wang Y, Norman E, Sheinin A, Pita MA, Yizhar O, Mughal MR, Stuenkel E, van Praag H, Mattson MP, Ashery U Neuron-specific expression of tomosyn1 in the mouse hippocampal dentate gyrus impairs spatial learning and memory. Neuromolecular Med. 2013 Jun;15(2):351-63. [IF# 3.885; ranked 77 of 252 journals in Neurosciences, C].
      20. Cheng A, Wan R, Yang JL, Kamimura N, Son TG, Ouyang X, Luo Y, Okun E, Mattson MP. Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines. Nat Commun. 2012 Dec 4;3:1250. [IF# 10.015; ranked 3 of 56 journals in Multidisciplinary Sciences, A+].
      21. Kashiwaya Y, Bergman C, Lee JH, Wan R, Todd King M, Mughal MR, Okun E, Clarke K, Mattson MP, Veech RL. A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease. Neurobiol Aging. 2012 Dec 29. [IF# 6.166; ranked 1 of 47 journals in Geriatrics and Gerontology, A+].
      22. Chigurupati S, Mughal MR, Okun E, Das S, Kumar A, McCaffery M, Seal S, Mattson MP. Effects of cerium oxide nanoparticles on the growth of keratinocytes, fibroblasts and vascular endothelial cells in cutaneous wound healing. Biomaterials. 2013 Mar;34(9):2194-201. [IF# 8.312; ranked 2 of 76 journals in Biomedical Engineering, A+].
      23. Okun E, Barak B, Saada-Madar R, Rothman SM, Griffioen KJ, Roberts N, Castro K, Mughal MR, Pita MA, Stranahan AM, Arumugam TV, Mattson MP. Evidence for a Developmental Role for TLR4 in Learning and Memory. PLoS One. 2012;7(10):e47522. doi: 10.1371/journal.pone.0047522. [IF# 3.73; ranked 7 of 56 journals in Multidisciplinary Sciences, A].

      Prof. Opatowsky Yarden

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        Dr. Shohat-Ophir Galit

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        media

        Publications

        1. G. Shohat-Ophir, K R. Kaun, R. Azanchi, H. Mohammed, and U. Heberlein Sexual deprivation increases ethanol intake in Drosophila. (2012) Science. 335:1351-5. (Recommended by Faculty of 1000 as a must to read).


        2. Guenebeaud C, Goldschneider D, Castets M, Guix C, Chazot G, Delloye-Bourgeois C, Eisenberg-Lerner A, Shohat G, Zhang M, Laudet V, Kimchi A, Bernet A, Mehlen P. (2010) The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase. Mol Cell. 40: 863-876.


        3. Corl AB, Berger KH, Ophir-Shohat G, Gesch J, Simms JA, Bartlett SE, Heberlein U. (2009) Happyhour, a Ste20 family kinase, implicates EGFR signaling in ethanol-induced behaviors. Cell. 137(5):949-60.


        4. Gozuacik D, Bialik S, Raveh T, Mitou G, Shohat G, Sabanay H, Mizushima N, Yoshimori T, and Kimchi A. (2008) DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagoc cell death. Cell Deah Differ. 15:1875-86.


        5. Citri A, Harari D, Shohat G, Ramakirsham P, Gan J, Eisenstein M, Kimchi A, Wallach D, Pietrokovski A and Yarden A. (2006) Hsp90 recognizes a common surface on client kinases. J Biol Chem. 19;281(20):14361-9.


        6. Shani G, Marash L, Gozuacik D, Bialik S, Teitelbaum L, Shohat G, Kimchi A. (2004) Death-associated protein kinase phosphorylates ZIP kinase, forming a unique kinase hierarchy to activate its cell death functions. Mol. Cell Biol. 24:8611-26.


        7. Toledano-Katchalski H, Kraut J, Sines T, Granot-Attas S, Shohat G, Gil-Henn H, Yung Y, Elson A. (2003) Protein tyrosine phosphatase epsilon inhibits signaling by mitogen-activated protein kinases. Mol. Cancer Res. 7:541-50.


        8. Shohat G, Spivak-Kroizman T, Eisenstein M, Kimchi A. (2002) The regulation of death-associated protein (DAP) kinase in apoptosis. Eur. Cytokine Netw. 13:398-400.


        9. Shohat G, Shani G, Eisenstein M, Kimchi A. (2002) The DAP-kinase family of proteins: study of a novel group of calcium-regulated death-promoting kinases. Biochim. Biophys. Acta.1600:45-50.


        10. Henis-Korenblit S, Shani G, Sines T, Marash L, Shohat G, Kimchi A. (2002) The caspase-cleaved DAP5 protein supports internal ribosome entry site-mediated translation of death proteins. Proc. Natl. Acad. Sci. USA. 99:5400- 5.

        11. Shohat G, Spivak-Kroizman T, Cohen O, Bialik S, Shani G, Berrisi H, Eisenstein M, Kimchi A. (2001) The pro- apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation- based mechanism. J. Biol. Chem. 276:47460-7.


        12. Seluanov A, Gorbunova V, Falcovitz A, Sigal A, Milyavsky M, Zurer I, Shohat G, Goldfinger N, Rotter V. (2001) Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53. Mol. Cell Biol. 21:1552-64.

        Prof. Susswein Abraham

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          Prof. Yadid Gal

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