Immunology and Cancer Research

Immunology deals in research of the immune system – the system that protects the body against disease agents and cancerous tumors, helps in healing injuries to tissues and can also learn and remember the experience it accumulated in previous responses. The immune system functions as a complex network of actions, responses and reciprocal actions. As the only biological system except for the brain which continuously learns and remembers its experiences, the immune system identifies potential harmful agents that invade the body, decides on a course of action, initiates certain responses and learns from them. The immune system has several defense mechanisms at its disposal – mainly the lymphoid cells, each of which is directed towards a particular antigen (foreign agent). There are several such cell types. For example, B lymphocytes produce antibodies that bind to the attacking pathogens, whereas T lymphocytes kill cells that are infected with a virus or tumor cells, or coordinate communication within this system. The system uses its weapons and enforces its sophisticated multi-stage decisions and defense strategy in a way especially adapted to the one of many challenges it faces. In spite of laborious studies, researchers are as yet unable to explain the entire mode of action of the immune system, not to speak of predicting its responses to manipulations that have not yet been tried, such as vaccines, drugs and implantations. It is not enough to understand how each component or a few components together function. We must understand the behavior of the entire system, as a product of all the behaviors and complex interrelations between all the cells in the system, if we want to increase its defense and error correction abilities. This is a fascinating challenge that is today facing research in these areas. Cancer research deals in factors that cause the development of cancerous tumors and their metastases. A large part of research today focuses on the identification of the molecular defects that take place in cancerous cells by focusing on genes whose impaired function leads to the development of cancer. These genes are divided into two main groups: oncogenes whose activity is increased in cancerous cells, and cancer-inhibiting genes whose activity is weakened or silenced in cancerous tumor cells. The research also deals in the development of ways to improve the detection of the cancerous tumor in the early stages of its development, in the development of new anti-cancer drugs and in determining the appropriate therapy for a tumor according to its specific molecular defects, in the response of the immune system against tumors and in ways to improve this response.

Prof. Barda-Saad Mira

Prof.
Email: 
Telephone: 
Fax: 
Mail address: 
Location: 

Publications

  1. Barda-Saad, M. Sredni, D., Zemer, R., Lenz, R. and Rozensajn L.A. (1990). T-lymphocyte colony enhancing factor. Harefuah 118: 92-5.
  2. Barda-Saad, M., Zipori, D., Globerson, A., Zhang, A.S. and Rozenszajn, L.A. (1996). Selective adhesion of immature thymocytes to bone marrow stromal cells: relevance to T cell lymphopoiesis.Exp Hematol. 24: 386-91.
  3. Barda-Saad, M., Zhang, A.S., Zipori, D. and Rozenszajn, L.A. (1997). Adhesion of thymocytes to bone marrow stroma cells: regulation by bFGF and IFN-gamma. Stem Cells 15: 229-36.
  4. Yu, S., Wang, S.L., Zhang, H.W., Huang, Z., Abel, L., Barda-Saad, M., Zipori, D. and Globerson, A. (1998). Effect of aging on the expression of surface antigen in mouse thymocytes. Acta Zoologica Sinica, 44:466-474.
  5. Barda-Saad, M., Rozenszajn, LA, Ashush, H., Shav-Tal, Y., Ben-Nun, A. and Zipori, D. (1999). Adhesion molecules involved in the interactions between early T-cells and mesenchymal bone marrow stromal cells. Exp Hematol. 27: 834-44.
  6. Ashush, H., Rozenszajn, LA, Blass, M., Barda-Saad, M., Azimov, D., Radnay, J., Zipori, D. and Rosenschein U. (2000). Apoptosis induction of human myeloid leukemic cells by ultrasound exposure. Cancer Res. 60:1014-20.
  7. Zipori, D., Barda-Saad, M. (2001). Role of activin A in negative regulation of normal and tumor B lymphocytes. J. Leukoc. Biol. 69:867-73.
  8. Shoham, T., Sternberg, D., Brosh, N., Barda-Saad, M. and Zipori D. (2001). The promotion of plasmacytoma growth by mesenchymal stroma is antagonized by basic fibroblast growth factor induced activin A. Leukemia 15:1102-10.
  9. Barda-Saad, M., Shav-Tal, Y., Rozenszajn, L.A., Cohen, M., Zauberman, A., Karmazyn, A., Parameswaran, R, Schori, H, Ashush, H., Ben-Nun, A. and Zipori D. (2002). The mesenchyme expresses T cell receptor mRNAs: relevance to cell growth control. Oncogene 21:2029-36.
  10. Shoham, T., Parameswaran, R., Shav-Tal, Y., Barda-Saad, M., and Zipori D. (2003). The Mesenchymal stroma negatively regulates B cell lymphopoiesis through the expression of activin A.Ann. N Y Acad. Sci. 996:245-260.
  11. Barda-Saad, M.,  Braiman, A.,  Titerence, R.,   Bunnell, S.C.,   Barr, V.A.,  and Samelson,  L.E. (2005) Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton.Nature Immunology 6:80-89.
  12. Houtman, J.C., Houghtling, R., Barda-Saad, M., Toda, Y., Schwartzberg, PL., and Samelson, LE. (2005). Early phosphorylation kinetics of proteins involved in proximal T-cell receptor-mediated signaling pathways. J. Immunol. 15:2449-2458.
  13. Houtman, J.C., Barda-Saad, M. and Samelson, L.E. (2005). Examining multiprotein signaling complexes from all angles. The use of complementary techniques to characterize complex formation at the adapter protein LAT. FEBS J. 272:5426-35.
  14. Barda-Saad, M., Braiman, A., Titerence, R., Barr, V. and Samelson, L.E. (2006). T cell antigen receptor engagement induced cytoskeleton re-organization. CCR Frontiers in Science (Published by the National Cancer Institute’s Center for Cancer Research, NIH).
  15. Braiman, A., Barda-Saad, M. and Samelson, L.E. (2006). Recruitment and activation of PLCg1in T-cells: a new insight into old domains. EMBO J. 25:774-84.
  16. Barr, V.A., Balagopalan-Bhise, L., Barda-Saad, M., Polishchuk, R., Boukari, H.,
    Bunnell, S.C., Bernot, K.M., Toda, Y., Nossal, R., and Samelson,  L.E. (2006). T-cell antigen receptor-induced signaling complexes: Internalization via a cholesterol-dependent endocytic pathway. Traffic 7:1143-1163.
  17. Houtman, J.C., Yamaguchi, H., Barda-Saad, M., Bowden, B., Schuck, P., Appella, E., and Samelson, LE. (2006). Oligomerization of signaling complexes by the multipoint binding of Grb-2 to both LAT and Sos1. Nature Struct. Mol. Biol. 13:798-805.
  18. Balagopalan, L., Barr, V.A., Sommers, C.L., Barda-Saad, M., Goyal, A., Isakowitz, M.S. and Samelson, L.E. (2007). c-Cbl mediated regulation of LAT-nucleated signaling complexes. Mol. Cell. Biol. 27:8622-8636.
  19. Sommers, C., Gurson, J.M., Surana, R., Barda-Saad, M., Lee, J., Kishor, A., Li, W.,
    Gasser, A.J., Barr, V., Miyaji, M., Love, P. and Samelson, L.E. (2008) Bam-32: a novel mediator of Erk activation in T cells. Int. Immunol. 20:811-818.
  20. Shani N, Rubin-Lifshitz, H., Sccolnick, K., Peretz-Chohen Y. Shkolnik, K., Shnider, V., Cohen, M., Shav-Tal, Y., Barda-Saad, M. and Zipori D. (2009) Incomplete T-cell receptor-beta peptides target the mitochondrion and induce apoptosis. Blood. 9:3530-3541.
  21. Barda-Saad, M, Shirasu, N., Pauker M.H, Hasan, N., Perl, O., Balbo, A., Yamaguchi, H., Houtman, J., Appella, E., Schuck, P. and Samelson, LE. (2010) Cooperative interactions at the SLP-76 complex are critical for actin polymerization. EMBO J. 29:2315-2328Single Corresponding author
  22. Reicher, B. and Barda-Saad, M. (2010). Multiple Pathways leading from the T-cell antigen receptor to the actin cytoskeleton network. FEBS Lett. 584:4858-4864.  Single Corresponding author
  23. Hazani, M. and Barda-Saad, M. (2010). Studies of novel interactions between Nck and VAV SH3 domains. Comm. Integ. Biol. 4:175-177Invited, Single Corresponding author
  24. Pauker, H.M., Reicher, B., Fried, S., Perl, O., and Barda-Saad, M. (2011) Functional cooperation between the proteins Nck and ADAP is fundamental for actin reorganization. Mol Cell Biol. 31;2653-2666.  Single Corresponding author
  25. Pauker, H.M., Hassan, N. Noy, E. Reicher, B. and Barda-Saad, M. (2012) Studying the dynamics of SLP-76, Nck, and Vav1 multimolecular complex formation in live human cells with triple-color FRET.Science Signaling 5(221):rs3 (cover). Single Corresponding author
  26. Reicher, B., Joseph, N., David, A., Perl, O. and Barda-Saad, M. (2012) Ubiquitylation-dependent negative regulation of WASp is essential for actin cytoskeleton dynamics. Mol. Cell. Biol. 32:3153.Single Corresponding author
  27. Noy, E., Fried, S. Matalon, O. and Barda-Saad M. (2012) WIP remodeling actin behind the scenes: How WIP reshapes immune and other functions. Int. J. Mol. Sci. 13:7629. Single Corresponding author
  28. Reicher, B., Perl, O., Matalon, O. and Barda-Saad, M. (2012) WASp and WAVE proteins: from structure, through function, to clinical aspects. Review, J. Clin. Cell. Immunol.,http://dx.doi.org/10.4172/2155-9899.S12-001Single Corresponding author
  29. Pauker, H.M., Noy, E. and Barda-Saad, M. (2013) Following the dynamics of signaling protein interactions in live activated T cells. JoVEhttp://www.jove.com/video/50076Single Corresponding author
  30. Ovadia, A., Livneh, A., Feld, O., Ben-Zvi, I., Kukuy, E., Kivity, S., Lidar, M., Barda-Saad, M. and Shinar, Y. (2013) T helper 17 polarization in familial Mediterranean fever. Genes & Immun. 1-5. doi: 10.1038/gene.2013.6.
  31. Joseph, N., Reicher, B. and Barda-Saad, M. (2013) The calcium feedback loop and T-cell activation: how the cytoskeleton networks control intracellular calcium levels. Biochimica et Biophysica Acta (BBA) – BiomembranesInvited, 105:481-93. Single Corresponding author
  32. Reicher, B., Matalon, O. and Barda-Saad, M. (2013) WASp function in T cell signaling microclusters. Immunol. RevInvited, 256:10-29. Single Corresponding author
  33. Haba, N.Y., Gross, R., Novacek, J., Shaked, H., Zidek, L., Barda-Saad, M. and Chill, J.H. (2013) NMR determines transient structure and dynamics in the disordered C-terminal domain of WASp interacting protein. Biophys. J. 105:481.
  34. Klieger, Y., Almogi-Hazan, O., Ish-Shalom, E., Pato, A., Pauker, H.M., Barda-Saad, M., Wang, L.  and Baniyash, M. (2013) Unique ζ-chain motifs mediate a direct TCR-actin linkage critical for immunological synapse formation and T-cell activation. Eur. J. Immunol. 44:58.
  35. Fried, S., Pauker, M. H., Reicher, B., Eliyahu, S., Matalon, O., Noy, E., Chill, J., and Barda-Saad, M. Conformational changes within the WIP:WASp actin-regulating complex: a triple-color FRET study.Science Signaling. Under Revision.  Single Corresponding author
  36. Elazari-Shalom, H., Shaked, H., Esteban-Martin, S., Salvatella, X., Barda-Saad, M. and Chill, J. (2014) NMR investigation of transient structure in the disordered N-terminal domain of WASp interacting protein. The FEBS JournalUnder revision.
  37. Borodianskiy-Shteinberg, T., Kalt, I., Kipper, S., Katz, S., Pauker, H. M., Barda-Saad, M., Gerber, D., and Sarid, R. (2014) The Nucleolar PICT-1/GLTSCR2 Protein Forms Homo-Oligomers. Journal of Molecular BiologyIn Press.
  38. Fried, S., Matalon, O., Noy, E., and Barda-Saad, M. (2014) WIP: More than a WASp interacting protein. Journal of leukocyte biologyUnder Revision.  Single Corresponding author
  39. Joseph, N., Reicher, B., Ahuvit D., Matalon, O., and Barda-Saad, M. (2014) Ubiquitylation-dependent downregulation of Nck  regulates its functional activity. FEBS Lett. 588:3808.
  40. Pauker, MH., Reicher, B., Wortzel1, I., Joseph, N., Jakubowicz, S., Perl, O., and Barda-Saad, M. (2014) WASp Family Verprolin-Homologous Protein-2 (WAVE2) and Wiskott-Aldrich Syndrome Protein (WASp) Engage in Distinct Downstream Signaling Interactions at the T Cell Antigen Receptor Site. JBC, 289:34503.
  41. Elazari-Shalom, H., Shaked, H., Esteban-Martin, S., Salvatella, X., Barda-Saad, M. and Chill, J. (2015) New insights into the role of the disordered WIP N-terminal domain revealed by NMR structural characterization. The FEBS Journal, 282:700.
  42. Ziv-Av, A., Giladi, ND., Lee, HK., Cazacu, S., Finniss, S., Xiang, C., Pauker, H.M., Barda-Saad, M., Poisson, L. and Brodie, C. (2015) RTVP-1 regulates glioma cell migration and invasion via interaction with N-WASP and hnRNPK. Oncotarget,  6:19826.
  43. Matalon, O., Fried, S., Ben-Shmuel, A., Pauker, H.M., Joseph, N., Keizer, D., Piterburg, M. and Barda-Saad, M. (2016) NK cell cytotoxicity is regulated by LAT and PLCgamma which serve as novel substrates of SHP-1. Science Signaling, 9 (429): ra54.

Chapters in Books

  1. Reicher, B., and Barda-Saad, M. (2011) Invited Book’s Chapter: The molecular mechanisms of actin regulatory proteins. Chapter 6 in: Actin: Structure, Functions and Disease (Online book edition). Eds: Victoria A. Consuelas and Daniel J. Minas. Nova Science Publishers, Inc.
  2. Elad, N., Reicher, B. and Barda-Saad, M. (2011) Invited Book’s Chapter: Stoichiometry of Signaling Complexes in Immune Cells: Regulation by the Numbers. Chapter 9 in: Stoichiometry and Research- The importance of quantity in biomedicine (Online book edition). Ed: Alessio Innocenti,InTech publications, Inc. 

Patents

  1. PCT/IL02/00130- #20040259196, T Cell Receptor variants expressed in Mesenchymal cells and uses thereof. Pending.
  2. PCT/IL02/00129 - #20040101931, Immunoglobulin Superfamily variants expressed in Mesenchymal cells and therapeutic uses thereof. US Pending. EP 1389236.
  3. #20070196365 – Immunoglobulin heavy chain variants expressed in mesenchymal cells and therapeutic uses thereof. Pending.

80-385-01 CONTROL MECHANISMS OF THE IMMUNE RESPONSE

Thursday, 14:00-16:00, 2nd semester

 

80-210-01 /10 INTRODUCTION TO IMMUNOLOGY

Sunday, 10:00-12:00, 2nd semester

Tuesday, 16:00-18:00, 2nd semester

 

80-930-01 SEMINAR (A)

Friday, 10:00-11:00, 1st semester

 

80-493-01 SEMINAR (B)

Friday, 10:00-12:00, 2nd semester

Prof. Ben-Aroya Shay

Prof.
Email: 
Telephone: 
Fax: 
Location: 

Publications

Recent publications

Lev I, Volpe M, Goor L, Levinton N, Emuna L, Ben-Aroya S. (2013) Reverse PCA, a systematic approach for identifying genes important for the physical interaction between protein pairs. PloS Genet. 9(10):e1003838. doi: 10.1371/journal.pgen.1003838.

Peters LZ, Hazan R, Breker M, Schuldiner M, Ben-Aroya S (2013) Formation and dissociation of proteasome storage granules are regulated by cytosolic pH. J. Cell Biol.  201(5):663-71. doi: 10.1083/jcb.201211146.

Peters LZ, Karmon O, David-Kadoch G, Hazan R, Yu T, Glickman MH, Ben-Aroya S (2015) The protein quality control machinery regulates its misassembled proteasome subunits. PLoS Genet. 11(4):e1005178. doi: 10.1371/journal.pgen.1005178

Prof. Cohen Cyrille

Prof.
Email: 
Telephone: 
Location: 

    Prof. Cohen Haim

    Prof.
    Email: 
    Telephone: 
    Fax: 
    Location: 

      Prof. Efroni Sol

      Prof.
      Email: 
      Telephone: 
      Location: 

        Prof. Ginsberg Doron

        Prof.
        Email: 
        Telephone: 
        Fax: 
        Location: 

          Dr. Hakim Ofir

          Dr.
          Email: 
          Telephone: 
          Fax: 
          Location: 

            Prof. Mehr Ramit

            Prof.
            Email: 
            Telephone: 
            Fax: 
            Location: 

              Prof. Nir Uri

              Prof.
              Email: 
              Telephone: 
              Location: 

              Publications

              List of Publications

              Chapters in Reviewed Books

              1.             Nir, U. (1976). Studies on the interaction between valinomycin and reticulocyte membranes and its effects on protein synthesis. M.Sc. Thesis, Bar-Ilan University:

              2.             Nir, U., Walker, M.D. & Rutter, W.J. (1987). Negative regulation of rat insulin 1 gene expression. In: Transcriptional Control Mechanisms (D.K. Granner, R. Rosenfield & S. Chang, Eds.), UCLA Symp. Mol. Cell. Biol., New Series Vol. 52, Alan R. Liss, N.Y., pp. 123-133.

              3.             Walker, M.D., Karlsson, O., Edlund, T., Barnett, J., Nir, U. & Rutter, W.J. (1987). Cell specific expression of the rat insulin gene. In: Molecular Approaches to Developmental Biology (R.A. Firtel & E.H. Davidson, Eds.), UCLA Symp. Mol. Biol. New Series Vol. 5, Alan R. Liss, N.Y., pp. 619-627.

              4.             Walker, M.D., Karlsson, O., Edlund, T., Barnett, J., Nir, U. Rutter, W.J. (1987). Identification of DNA sequences involved in expression of the rat insulin gene. In: Molecular Mechanisms in the Regulation of Cell Behavior (C. Waymouth, ed.), Alan R., Liss, N.Y., pp. 273-278.

              5.             Nir, U., Moss, L.G., Fodor, E., Meister, A., Weinrich, S., Melloul, D. & Rutter, W.J. (1987). Analysis of cellular factors binding to cis-acting regulatory elements of pancreatic genes. In: Mechanisms of Control of Gene Expression. UCLA Symp. Mol. Cell. Biol. New Series Vol. 67 (B. Cullen, L.P. Gage, M.A.W. Siddiqui, A.M. Skalka & H. Weissbach, eds), Alan R. Liss, N.Y., pp. 135-145.

              6.             Walker, M.D., Karlsson, O., Edlund, T., Nir, U., Barnett, J. Rutter, W.J. (1988). Regulation of rat insulin 1 gene expression. In: Selected Topics in Molecular Endocrinology (Y.F.C. Lau, ed.), Oxford University Press, pp. 59-74.

              Articles in Reviewed Journals

              7.             Herzberg, M. & Nir, U. (1980). Interaction between membranal properties and protein synthesis in reticulocytes: Influence of trypsinization on H3‑valinomycin action. Mol. Biol. Rep. 6: 131-141

              8.             Weissenbach, J., Chernajovsky, Y., Zeevi, M., Shulman, L., Soreq, H., Nir, U., Wallach, D., Perricaudet, M., Tiollaus, P. & Revel, M. (1980). Two interferon mRNAs in human fibroblasts: in vitro translation and E. coli cloning studies. Proc. Nat. Acad. Sci. USA 77: 7152-7156.

              9.             Mory, Y., Chernajovsky, Y., Feinstein, S., Chen, L., Nir, U., Weissenbach, J., Malpiece, Y., Tiollais, P., Marks, D., Lodner, M., Colby, C. & Revel, M. (1981) Synthesis of human interferon 1b in E. coli infected by a lambda phage recombinant containing a human genomic fragment. Eur. J. Biochem. 120: 197‑202.

              10.         Fellous, M., Nir, U., Wallach, D., Merlin, G., Rubinstein, M. & Revel, M. (1982). Interferon dependent induction of mRNA for the major histocompatibility antigens in human fibroblasts and lymphoblastoid cells. Proc. Nat. Acad. Sci. USA 79: 3082-3086.

              11.         Nir, U., Cohen, B., Chen, L & Revel, M. (1984). A human IFN-1b gene deleted of promoter sequences upstream from the TATA box is controlled post‑transcriptionally by ds RNA. Nucl. Acids Res. 12: 6979-6993.

              12.         Feinstein, S.I., Mory, Y., Chernajovsky, Y., Maroteaux, L., Nir, U., Lavie, V. & Revel, M. (1985). Family of human _a-interferon-like sequences. Mol. Cell. Biol. 5: 422-430.

              13.         Nir, U., Maroteaux, L., Cohen, B. & Mory, Y. (1985). Priming affects the transcription rate of human interferon 1b gene. J. Biol. Chem. 260: 14242-14247.

              14.         Nir, U., Walker, M.D. & Rutter, W.J. (1986). Regulation of rat insulin 1 gene expression: Evidence for negative regulation in non-pancreatic cells. Proc. Nat. Acad. Sci. U.S.A. 83: 3180-3184.

              15.         Nir, U., Fodor, E. & Rutter, W.J. (1988). Capturing Nuclear Sequence Specific DNA Binding Proteins Using SV40 Derived Minichromosomes. Mol. Cell. Biol. 8(2): 982-987.

              16.         Nir, U., Fodor, E., & Rutter, W.J. (1989). Detection of Enhancer Binding Proteins Using SV40 Derived Minichromosomes. DNA and Protein Engineering Techniques. 1(5): 61-65.

              17.         Fischman, K., Edman, J., Shackelford, G.M., Turner, J.A., Rutter, W.J. & Nir, U. (1990). A murine FER testis specific transcript (fer T) encodes A truncated FER protein. Mol. Cell. Biol. 10(1): 146-153.

              18.         Keshet, E., Itin, A., Fischman, K. & Nir, U. (1990). The testis-specific transcript (fer T) of the tyrosine kinase FER is expressed during spermatogenesis in a stage specific manner. Mol. Cell. Biol. 10(9): 5021-5025.

              19.         Nir, U., Ladan, H., Malik, Z. & Nitzan, Y. (1991) In vivo effects of porphyrins on Bacterial DNA.
              J. Photochem & Photobiol. 11: 295-306.

              20.         Hazan, B., Bern, O., Carmel, M., Lejbkowicz, F., Goldstein, R.S. & Nir, U. (1993) Fer T encodes a
              51 kDa meiosis specific nuclear tyrosine kinase. Cell Growth & Differentiation 4: 443-449.

              21.         Navon, A., Schwartz, Y., Hazan, B., Kassir, Y. & Nir, U. (1994) Meiosis dependent tyrosine phosphorylation of a yeast protein related to the mouse p51ferT. Mol. Gen. Genet. 244: 160-167.

              22.         Mittelman, M., Gardyn, J., Carmel, M., Malovani, H., Barak, Y. & Nir, U. (1995) Analysis of the Erythropoietin receptor gene in patients with myeloproliferative and myelodysplastic syndromes. Leukemia Research 20: 459-466.

              23.         Yaffe, A., Schwartz, Y., Hacohen, D., Kinar, Y., Nir, U. & Salzberg, S. (1996) Inhibition of 2’-5’A synthetase expression by antisense RNA interferes with interferon mediated antiviral and antiproliferative effect and induces anchorage independent cell growth. Cell Growth & Differentiation 7: 969-978.

              24.         Bern, O., Hazan, B. & Nir, U. (1997) Growth-dependent subnuclear localization of a 66 kDa phosphoprotein in FER protein overexpressing cells. FEBS Lett. 403: 45-50.

              25.         Halachmy, S., Bern, O., Schreiber, L., Carmel, M., Sharabi, Y., Shoham, J. & Nir, U. (1997) p94fer facilitates cellular recovery of gamma irradiated pre-T cells. Oncogene 14: 2871-2880.

              26.         Theodor, L., Shoham, J., Berger, R., Gokkel, E., Trachtenbrot, L., Simon, A.J., Brok-Simon, F.,
              Nir, U., Ilan, E., Zevin-Sonkin, D., Friedman, E. and Rechavi, G. (1997) Ubiquitous expression of a cloned murine thymopoietin RNA. Acta Haematol. 97: 153-163.

              27.         Salzberg, S., Hyman, T., Turm, H., Kinar, Y., Schwartz, Y., Nir, U., Lejbkowicz, F. and
              Huberman, E. (1997) Ectopic expression of 2-5A synthetase in human myeloid leukemia cells induces cell-growth arrest and facilitates the appearance of a myeloid differentiation marker. Cancer Res. 57: 2732-2740.

              28.         Schwartz, Y., Ben-Dor, I., Motro, B. and Nir, U. (1998) Tyrosine phosphorylation of the TATA Modulatory Factor (TMF) by the FER nuclear tyrosine kinases. FEBS Lett. 434: 339-345.

              29.         Ben-Dor, I., Bern, O., Tennenbaum, T. and Nir, U. (1999) The cell-cycle dependant nuclear accumulation of the p94fer tyrosine-kinase is regulated by its N-terminus and is affected by kinase-domain integrity and ATP binding. Cell Growth & Differentiation 10:113-129.

              30.         Sharabani-Yosef, O., Bak, A., Langzam, L., Lui, Z., Nir, U., Braiman, L., Sweadner, K.J. and Sampson, S.R. (1999) Rat skeletal muscle in culture expresses the a1 but not the a2 protein subunit isoform of the Na+/K+ pump. J. Cell. Physiol. 180: 236-244.

              31.         Carmel, M., Shpungin, S. and Nir, U. (2000) Role of positive and negative regulation in modulation of the Fer promoter activity. Gene 241: 87-99.

              32.         Orlovsky K., Ben-Dor, I., Priel-Halachmi, S., Malovany, H. and Nir, U. (2000) N-terminal sequences direct the autophosphorylation states of the FER tyrosine kinases in vivo. Biochemistry 39: 11084-11091.

              33.         Priel-Halachmi, S., Ben-Dor, I., Shpungin, S., Tennenbaum, T., Malovani, H., Bachrach, M., Salzberg, S. and Nir, U. (2000) FER kinase activation of Stat3 is determined by the N-terminal sequence. J. Biol. Chem. 275: 28902-28910.

              34.         Sharabani-Yosef, O., Bak, A., Nir, U. and Sampson, S.R. (2001). Na+/K+ pump expression in the L8 rat myogenic cell line: Effects of heterologous alpha subunit transfection. J. Cell. Physiol. 187:
              365-373.

              35.         Beery, R., Haimsohn, M., Wertheim, N., Hemi, R., Nir, U., Karasik, A., Kanety, H. and Geier, A. (2001) Activation of the insulin-like growth factor 1 signaling pathway by the antiapoptotic agents aurintricarboxylic acid and evans blue. Endocrinology 142: 3098-3107.

              36.         Dagon, Y., Dovrat, S., Vilchik, S., Hacohen, D., Shlomo, G., Sredni, B., Salzberg, S. and Nir, U. (2001) Double-stranded RNA-dependent protein kinase, PKR, down-regulates CDC2/cyclin B1 and induces apoptosis in non-transformed but not in v-mos transformed cells. Oncogene 20: 8045-8056.

              37.         Orlovsky, K., Theodor, L., Malovani, H., Chovers, Y., and Nir, U. (2002) Gamma Interferon Down-Regulates Fer and Induces its Association with Inactive Stat3 in Colon Carcinoma Cells. Oncogene 21: 4997-5001.

              38.         Sharabani-Yosef, O., Nir, U. and Sampson, S.R. (2002) Thyroid hormone up-regulates Na+/K+ pump a2 mRNA but not a2 protein isoform in cultured skeletal muscle. Biochim. Biophys. Acta 1573:
              183-188.

              39.         Taler, M., Shpungin, S., Salem, Y., Malovani, H., Pasder, O. and Nir, U. (2003) Fer is a downstream effector of insulin and mediates the activation of Stat3 in myogenic cells. Mol. Endocrinol. 17:
              1580-1592.

              40.         Perry, E., Tsruya, R., Levitzky, P., Pomp, O., Taler, M., Weisberg, S., Parris, W., Kulkarni, S., Malovani, H., Pawson, T., Shpungin, S. and Nir, U. (2004) TMF/ARA160 is a “BC box” containing protein that mediates the degradation of Stat3. Oncogene 23: 8908-8919.

              41.         Salem, Y., Shpungin, S., Pasder, O., Pomp, O., Taler, M., Malovani, H. and Nir, U. (2005) Fer kinase sustains the activation of ERK1/2 and the production of VEGF in hypoxic cells. Cell. Signaling 17(3): 341-353.

              42.         Pasder, O., Shpungin, S., Vilchick, S., Michaeli, S., Salem, Y., Malovani, H. and Nir, U. (2006) Down-regulation of Fer induces PP1 activation and cell-cycle arrest in malignant cells. Oncogene 25: 4194-4206.

              43.         Volpe, M., Shpungin, S., Barbi, C., Abraham, G., Malovani, H., Wides, R. and Nir, U. (2006) trnp: A conserved mammalian gene encoding a nuclear protein that accelerates cell-cycle progression. DNA & Cell Biol. 25: 331-339 (with cover).

              44.         Hayun, R., Shpungin, S., Malovani, H., Albeck, M., Okun, E., Nir*, U. and Sredni*, B. (2007) Novel involvement of the immunomodulator AS101 in IL-10 signaling, via the tyrosine kinase Fer. Ann NY Acad Sci. 1095:240-250 (* Equal contribution).

              45.         Pasder, P., Salem, Y., Yaffe, E., Shpungin, S. and Nir, U. (2007) Fer as a novel target for cancer therapy. Drugs of the Future 32: 61-70 (Review).

              46.         Abu, A., Frydman, M., Marek, D., Pras, E., Nir, U., Reznik-Wolf, H. and Pras, E. (2008) Deleterious mutations in the zinc finger 469 gene cause Brittle Cornea Syndrome. American J Hum. Genet. 82: 1217-1222.  

              47.         Kontorovich, T., Cohen, Y., Nir, U. and Friedman, E. (2009) Promoter methylation patterns of ATM, ATR, BRCA1, BRCA2 and P53 as putative cancer risk modifiers in Jewish BRCA1/BRCA2 mutation carriers. Breast Cancer Research and Treatment 116: 195-200.

              48.         Cohen, S. , Laitman, Y., Kaufman, B., Milgrom, R., Nir, U., Friedman,E. (2009) SULT1E1 and ID2 genes as candidates for inherited predisposition to breast and ovarian cancer in Jewish women. Fam Cancer. 8: 135-144.

              49.         Hikri, E., Shpungin, S. and Nir, U. (2009) Hsp90 and a tyrosine embedded in the Hsp90 recognition loop are required for the Fer tyrosine kinase activity. Cell.  Signaling. 21:588-596.

              50.         Hayun, R., Okun, E., Berrebi, A., Shvidel, L., Bassous, L., Sredni, B. and Nir, U. (2009)   Rapamycin and Curcumin induce apoptosis in primary resting B chronic lymphocytic leukemia cells. Leukemia and Lymphoma.  50: 625-632.

              51.         Avraham, G., Volpe, M., Shpungin, S. and Nir, U. (2009) TMF/ARA160 down-regulates pro-angiogenic genes and attenuates the progression of PC3   xenografts. Int. J. Cancer. 125: 43-53.

              52.         Vardi, A., Anikster, Y., Eisenkraft, A., Shohat, M., Abu-Much, J., Eisenkraft, S., Sredni, B. and Nir, U. (2009) A new genetic isolate of acrodermatitis enteropathica with a novel mutation. British J. Dermatol. 160: 1346-1348.

              53.         Kontrovich, T., Levy, A., Korostishevsky, M., Nir, U. and Friedman, E. (2010) Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. Int. J. Cancer  127:589-597.

              54.         Abrham, G., Dovrat, S., Bessler, H., Grossman, S., Nir, U. and Bergman, M. (2010) Inhibition of inflammatory cytokine secretion by plant-derived compounds Inuviscolide and Tomentoxin: The role of  NFkB and Stat1. The open pharmacology journal 4:36-44.

              55.         Lerer-Goldshtein,T., Shpungin, S., Bel, S., Perry, E., Motro, B., Goldstein, R.S., Itach Bar-Sheshet, S., Breitbart, H.and Nir. U. (2010) TMF/ARA160: a key regulator of sperm development. Developmental Biology  348:.12-21.

              56.         Don, J., Nir, U. and Breitbart, H. (2011) DMRT1 at the border between mitosis and meiosis. Asian J Androl. 13: 189-90.

              57.         Makovski, A., Yaffe , E. , Shpungin, S. and Nir, U. (2012) Intronic promoter drives the BORIS-regulated expression of FerT in colon carcinoma cells. J.Biol.Chem  24: 6100-6112.  

              58.         Makovski, A., Shpungin, S. and Nir,U. (2012) Down-regulation of Fer induces ROS generation accompanied by ATM and p53 activation in colon carcinoma cells. Cell Signal. 24: 1369-1374.

              59.         Bel, S., Elkis,Y., Lerer-Goldstein,T., Nyska, A., Shpungin, S., and Nir, U. (2012) Loss of TMF/ARA160 renders the colonic mucus refractory to bacterial colonization and diminishes intestinal susceptibility to acute colitis. J.Biol.Chem  287 : 25631-25639 (With a cover).

              60.         Elkis, Y., Bel, S., Goldstein –Lerrer, T. , Nyska, A., Creasy, D.M., Shpungin, S. and Nir, U. (2013) Testosterone deficiency accompanied with testicular and epididymal abnormalities in TMF-/- mice. Mol.Cel.Endocrinol. 365: 52-63.

              61.         Bel, S., Elkis, Y., Lerrer-Goldstein, T., Ban-Horin, S., Niska, A., Shpungin, S. and Nir, U. (2014) Reprogrammed and transmissible microbiota confer diminished susceptibility to induce colitis in TMF-/-  mice.  Proc.Nat.Acad.Sci.USA 111:4964-4969.

              62.         Yaffe, E., Hikri, E., Elkis, Y. Cohen, O., Segal, A.,  Nakovski, A., Varvak, A., Shpungin, S. and Nir, U. (2014) Oncogenic properties of a spermatogenic meiotic variant of Fer kinase expressed in somatic cells. Cancer Res. 74: 6474-6485.

              63.         Zolberg-Relevy, N., Ruhl, R., Harari, A., Grosskopf, I. , Barshack, I., Ben-Amoz, A., Nir, U., Gottlieb, H., Kamari, Y., Harats, D., and Shaish, A. (2015) 9-cis b-carotene inhibits Atherosclerosis Development in Female LDLR-/- Mice. Functional Foods in Health and Disease 5(2):67-79.  

              64.         Elkis, Y., Bel, S., Shpungin, S. and Nir, U. (2015) TMF/ARA160 governs the spatial Golgi orientation during sperm development. PLos One  (Under review).      

              Patents

              65.         U.S. Patent No. 7,442,781 (2008) "Diagnosis, prevention and treatment of cancer". Inventors: Uri Nir, Erez Perry and Sally Shpungin.

              66.         PCT US patent application no. IL2007/000360 (2007) "Methods and systems for searching for regulators of the Fer protein and for monitoring the effects of the Fer protein".
              Inventors: Uri Nir, Orel Pasder, Sally Shpungin and Etai Yaffe. 

              Dr. Opatowsky Yarden

              Dr.
              Email: 
              Telephone: 
              Fax: 
              Location: 

                Prof. Shav-Tal Yaron

                Prof.
                Email: 
                Telephone: 
                Fax: 
                Location: 

                  Prof. Sredni Benjamin

                  Prof.
                  Email: 
                  Telephone: 
                  Location: 

                    Dr. Yissachar Nissan

                    Dr.
                    Email: 
                    Telephone: 
                    Location: 
                      Syndicate content